Adherence to oxidative balance score is inversely associated with the prevalence of stroke: results from National Health and Nutrition Examination Survey 1999–2018

FYI. Anytime I see the word integrative I assume woo, so I don't know about this.

Woo medicine definition. "Woo" (sometimes "woo-woo") This is the term scientists and clinicians tend to use to describe a whole gamut of pseudoscience and quack medicine practices based on irrational beliefs and spiritualism.

Adherence to oxidative balance score is inversely associated with the prevalence of stroke: results from National Health and Nutrition Examination Survey 1999–2018

Jiarui Chen¹Jianjian Liu¹Zhaowen Gu¹Jiayong Fan¹Shuxin Lei¹Qia Zhang¹Kai Pan¹Yongjie Wang^1,2,3*

• ¹The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China
• ²Clinical Research Center for Neurological Diseases of Zhejiang Province, Hangzhou, China
• ³Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, China

Introduction: The relationship between oxidative balance score (OBS), an emerging integrative metric for assessing individual redox homeostasis, and the prevalence of stroke in the general population remains unknown. We aimed to explore these relationships in the National Health and Nutrition Examination Survey (NHANES). We investigated the relationship between the oxidative balance score (OBS) and stroke prevalence using NHANES data from 1999–2018.

Methods: We included eligible individuals from NHANES 1999–2018. OBS calculations were based on previously validated methods, and stroke diagnoses were based on self-reports in questionnaires. Multivariable logistic regression analyses were used to examine the independent associations of overall, dietary, and lifestyle OBS with stroke prevalence. In addition, restricted cubic spline (RCS), stratified analysis, and sensitivity analysis were used.

Results: We included 25,258 participants aged 20–85 years, in which the prevalence of stroke was 2.66%. After adjusting for all confounders, overall and dietary OBS, but not lifestyle OBS, were inversely associated with the prevalence of stroke [odds ratios and 95% confidence intervals of 0.97 (0.96, 0.99) and 0.98 (0.96, 0.99) for overall and dietary OBS, respectively, both p < 0.05]. In addition, there was a dose-response relationship between overall and dietary OBS and stroke prevalence. The RCS showed that these relationships were linear. Stratified analyses indicated that socioeconomic status (SES) significantly influenced the relationship between all OBS and stroke prevalence.

Conclusion: Dietary OBS, but not lifestyle OBS, had an inverse relationship with the prevalence of stroke in the general population. SES significantly influenced the protective effect of OBS against stroke. These findings emphasize the importance of integrated antioxidant properties from diet for stroke prevention.

1 Introduction

Stroke, including ischemic and hemorrhagic stroke, is the leading cause of disability and death worldwide (1). Global stroke statistics reveal that stroke is the second most common cause of disability and mortality, and its disease burden is substantial in both low- and high-income countries (2). Stroke is the disease leading to the highest disability-adjusted life-years lost in China, with approximately 2 million new cases each year (3). The incidence of stroke is highest in the elderly population; however, recent epidemiologic studies have shown that the incidence of stroke in young adults (<50 years of age) is increasing dramatically (4). Evidence-based findings suggest that up to 85% of strokes are preventable; therefore, identifying modifiable risk factors for stroke is a major instrument for stroke prevention and management of stroke populations (5).

Oxidative stress is an important component of the pathogenesis of stroke, which is inextricably associated with neuroinflammation and ischemia-reperfusion injury (6, 7). Dietary and other lifestyle modifications, which are recognized as central in stroke prevention, are closely linked to homeostasis of the individual’s redox state. There is a large body of evidence linking nutritional deficiencies and poor lifestyles such as obesity status and harmful alcohol consumption to stroke risk and prognosis (8–10). However, whether there are independent and/or combined effects of oxidative stress-related dietary components and lifestyle on the prevalence of stroke in the general population remains unstudied.

More at link.

The oxidative balance score (OBS) is an emerging indicator in recent years for assessing the homeostasis of an individual’s redox balance, which consists of a dietary OBS, and a lifestyle OBS (11). OBS has demonstrated its clinical relevance in extensive epidemiologic studies and is associated with a variety of diseases such as cancer (12), chronic kidney disease (13), and depression (14). Exploring whether OBS is associated with the prevalence of stroke in the general population could help potential stroke prevention strategies based on OBS. We here explore these relationships using a nationwide population-based survey, the National Health and Nutrition Examination Surveys (NHANES).