Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 20, 2024

Blessed Thistle Enhances Nerve Regeneration

 If you have competent? doctors and hospital they will make sure this gets tested for nerve regeneration in the brain! Maybe by using nanocarriers to get across the blood brain barrier. But then, your competent? doctor already knows about nanocarriers, so you don't need to remind them of it.

Do you prefer your  doctor and hospital incompetence NOT KNOWING? OR NOT DOING?

Blessed Thistle Enhances Nerve Regeneration

Summary: Cnicin, a compound derived from the plant Blessed Thistle, significantly enhances nerve regeneration. The study shows that Cnicin can accelerate the growth of axons, the long fibers of nerve cells, which is crucial for the recovery of nerve function after injury.

This new finding was demonstrated in animal models and human cell cultures, where Cnicin treatment led to rapid improvements in paralysis and neuropathy symptoms. Remarkably, Cnicin can be administered orally, offering a practical advantage over injectable treatments and highlighting its potential for broader clinical application.

Key Facts:

  1. Cnicin, extracted from Blessed Thistle, has been shown to speed up axon growth, essential for nerve repair.
  2. The compound’s effectiveness was observed in both animal models and human cells, with treated subjects showing quicker recovery from nerve damage.
  3. The study emphasizes the need for further clinical trials to determine the optimal dosage, as Cnicin operates within a narrow therapeutic window.

Source: University of Cologne

Blessed thistle (Cnicus benedictus) is a plant in the family Asteraceae and also grows in our climate. For centuries, it has been used as a medicinal herb as an extract or tea, e.g. to aid the digestive system.

Researchers at the Center for Pharmacology of University Hospital Cologne and at the Faculty of Medicine of the University of Cologne have now found a completely novel use for Cnicin under the direction of Dr Philipp Gobrecht and Professor Dr Dietmar Fischer.

This shows blessed thistle.
Administering a daily dose of Cnicin to mice or rats helped improve paralysis and neuropathy much more quickly. Credit: Neuroscience News

Animal models as well as human cells have shown that Cnicin significantly accelerates axon (nerve fibres) growth. The study ‘Cnicin promotes functional nerve regeneration’ was published in Phytomedicine.

Rapid help for nerves

Regeneration pathways of injured nerves in humans and animals with long axons are accordingly long. This often makes the healing process lengthy and even frequently irreversible because the axons cannot reach their destination on time.

An accelerated regeneration growth rate can, therefore, make a big difference here, ensuring that the fibres reach their original destination on time before irreparable functional deficits can occur.

The researchers demonstrated axon regeneration in animal models and human cells taken from retinae donated by patients. Administering a daily dose of Cnicin to mice or rats helped improve paralysis and neuropathy much more quickly.

Compared to other compounds, Cnicin has one crucial advantage: it can be introduced into the bloodstream orally (by mouth). It does not have to be given by injection.

“The correct dose is very important here, as Cnicin only works within a specific therapeutic window. Doses that are too low or too high are ineffective. This is why further clinical studies on humans are crucial,” said Fischer.

The University of Cologne researchers are currently planning relevant studies. The Center for Pharmacology is researching and developing drugs to repair the damaged nervous system.

Funding: The current study received funding of around 1,200,000 euros from the Federal Ministry of Education and Research within the framework of the project PARREGERON.

About this nerve regeneration and supplements research news

Author: Anna Euteneuer
Source: University of Cologne
Contact: Anna Euteneuer – University of Cologne
Image: The image is credited to Neuroscience News

Original Research: Open access.
Cnicin promotes functional nerve regeneration” by Dietmar Fischer et al. Phytomedicine

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