I can't see anything here that helps with recovery! It describes something but how that helps recovery eludes me.
Evolution of Brain Activation with Good and Poor Motor Recovery after Stroke
Leeanne M. Carey, PhD, David F. Abbott, PhD, Gary F. Egan, PhD,
Graham J. O’Keefe, PhD, Graham D. Jackson, MD, Julie Bernhardt, PhD,
and Geoffrey A. Donnan, MD
Objective.
To characterize the evolution of brain activation in stroke patients with variable motor recovery and
quantify changes relative to healthy controls.
Methods.
Serial PET activation studies, using a simple finger-
tapping task, and quantitative measures of motor performance were obtained in 9 patients (2–7 weeks
post stroke and 6 months later) and compared with serial
healthy volunteer data.
Results.
Patients with moderate
impairment and good recovery (n = 5) activated the primary sensorimotor cortex (SM1) contralateral to the
paretic hand moved, bilateral supplementary motor area
(SMA), contralateral cingulate gyrus, and ipsilateral lateral premotor cortex. Activation in the bilateral SMA was
greater at the initial study but reduced over time compared to healthy controls and poor recoverers. Patients
with severe impairment and poor recovery (n = 4)
showed limited activation of contralateral SM1 and SMA
at both studies and no significant change over time. A
posterior shift in SM1 activation was evident in good and
poor recoverers.
Conclusions.
Activation of typical
motor regions and recruitment of additional sites occur
subacutely poststroke, with evolution to normal patterns
in moderately impaired patients who recover well. In
comparison, severely impaired, poor-recovery patients
show persistent, reduced activation. Dynamic changes
in SMA, differentially observed in good recoverers over
6 months, highlight its importance in recovery.
More at link.
No comments:
Post a Comment