40
Hz transcranial alternating current stimulation (tACS) has proven to be
an effective treatment for improving cognition, a crucial factor in
motor learning.If this statement is true, where is the protocol that your hospital is using? Or is your competent? hospital not using this?
Gamma oscillations induced by 40-Hz visual-auditory stimulation for the treatment of acute-phase limb motor rehabilitation after stroke: study protocol for a prospective randomized controlled trial
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Xiaomi Yu
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Minhui Lai
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Yuanli Li
Shanghai University of Traditional Chinese Medicine
Yiting Yang
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Yong Qin
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Min Yu
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Feng Wang
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
Cong Wang
Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine
https://orcid.org/0000-0003-2289-2794
https://doi.org/10.21203/rs.3.rs-3346592/v1
This work is licensed under a CC BY 4.0 License
Background:
40 Hz transcranial alternating current stimulation (tACS) has proven to be an effective treatment for improving cognition, a crucial factor in motor learning. However, current studies are predominantly focused on the motor cortex, and the potential brain mechanisms responsible for the therapeutic effects are still unclear. Given the interconnected nature of motor learning within the brain network, we have proposed a novel approach known as multitarget tACS. This study aims to ascertain whether multitarget tACS is more effective than single-target stimulation in stroke patients and to further explore the potential underlying brain mechanisms by using techniques such as transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI).
Methods:
This study employs a double-blind, sham-controlled, randomized controlled trial design with a 2-week intervention period. Both participants and outcome assessors will remain unaware of treatment allocation throughout the study. Thirty-nine stroke patients will be recruited and randomized into three distinct groups, including the sham tACS group (SS group), the single-target tACS group (ST group), and the multitarget tACS group (MT group), at a 1:1:1 ratio. The primary outcomes are series reaction time tests (SRTTs) combined with electroencephalograms (EEGs). The secondary outcomes include motor evoked potential (MEP), central motor conduction time (CMCT), short interval intracortical inhibition (SICI), intracortical facilitation (ICF), magnetic resonance imaging (MRI), box and block test (BBT) and blood sample RNA sequencing. The tACS interventions for all three groups will be administered over a 2-week period, with outcome assessments conducted at baseline (T0) and 1 day (T1), 7 days (T2), and 14 days (T3) of the intervention phase.
Discussion:
The study’s findings will determine the potential of 40 Hz tACS to improve motor learning in stroke patients. Additionally, it will compare the effectiveness of multitarget and single-target approaches, shedding light on their respective improvement effects. Through the utilization of techniques such as TMS and MRI, the study aims to uncover the underlying brain mechanisms responsible for the therapeutic impact. Furthermore, the intervention has the potential to facilitate motor learning efficiency, thereby contributing to the advancement of future stroke rehabilitation treatment.
Trial registration: Chinese Clinical Trial Registry ChiCTR2300073465. Registered on July 11, 2023.
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