Ask your competent? doctor and hospital if this test became standard procedure to document damage from the stroke and point DIRECTLY TO REHAB PROTOCOLS THAT DELIVER 100% RECOVERY!
If they did nothing in the last decade; RUN AWAY!
Metabolic profile of motor cortex in stroke
Sorin C. Craciunas, MD, PhD
1
, William M. Brooks, PhD
1
,
Randolph J. Nudo, PhD
1
, Elena A. Popescu, PhD
1
, In-Young Choi, PhD
1
, Phil Lee, PhD
1
,
Hung-Wen Yeh, PhD
1
, Cary R. Savage, PhD
1
, and Carmen M. Cirstea, MD, PhD
1
OnlineFirst Version of Record
- Jan 9, 2013
Abstract
Background.
Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor
areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies.
Objective.
We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand
representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in
hemiparetic persons.
Methods.
In 20 participants at >6 months postonset of a subcortical ischemic stroke and 16 age- and
sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic
resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1),
dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and
distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores
were explored. Results. N-Acetylaspartate was lower in M1 (P = .04) and SMA (P = .004) and myo-inositol was higher in
M1 (P = .003) and PMd (P = .03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere
in controls. N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P = .04). Significant
positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional
M1 and shoulder/elbow FMUE subscores (P = .02, .01, .02, and .02, respectively).
Conclusions.
Our preliminary results
demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes
in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes
to arm motor impairment.
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