Your competent? doctor has known of this earlier research and created protocols on it? NO? So you don't even have a decent doctor, do you?
Well shit this was written about in April 2016, human testing also.
The impact of mastication on cognition: evidence for intervention and the role of adult hippocampal neurogenesis April 2016
No chewing because of swallowing problems? I bet chewing gum would work,
Effects of chewing on cognitive processing speed - gum July 2013
The latest here:
Effect of mastication on adult hippocampal neurogenesis in mice
Showa Univ J Med Sci 35（4）, 171-177, December 2023Effect of mastication on adult hippocampal neurogenesis in mice
Fumika Miyano＊1
, Junichi Watahiki1
, Junichi Tanaka2
,
Tomoki Nampo1
, Tomohiro Taguchi1
, Yuta Ichikawa1
,
Kana Nose1
, Kenji Mishima2 and Koutaro Maki1
Received: 28 December 2020 / Accepted: 15 February 2023
Abstract
The number of neurons in the brain increases over time, even in adults. This phenomenon,
known as “neurogenesis”, is associated with neural stem cells present only in the dentate
gyrus of the hippocampus. However, the frequency of neurogenesis is regulated by various
factorsand mastication has been suggested as one such factor. In the present study, we
examined the effects of varying the input of masticatory stimulation on neural stem cells using
feed with different degrees of hardness. Male C57BL/5 mice were used in a comparative
study. After weaning at 3 weeks old, experimental mice were fed a soft or hard diet for 4
or 11 weeks. To study the dynamic behavior of neural stem cells, the expression of two
markers（nestin, a neural stem/progenitor cell marker; and doublecortin, a microtubule-associated protein）was quantitatively analyzed via immunostaining, whereas gene expression was analyzed by real-time polymerase chain reaction （RT-PCR）. Immunostaining-based quantification and gene expression analysis by RT-PCR revealed the decreased expression of markers in the hippocampus in the soft diet group compared to that in the hard diet group. Based on these results, the repression of neurogenesis by a soft diet was associated with changes in neural stem cells in the hippocampus and the frequency of neurogenesis.
Fumika Miyano＊1
, Junichi Watahiki1
, Junichi Tanaka2
,
Tomoki Nampo1
, Tomohiro Taguchi1
, Yuta Ichikawa1
,
Kana Nose1
, Kenji Mishima2 and Koutaro Maki1
Received: 28 December 2020 / Accepted: 15 February 2023
Abstract
The number of neurons in the brain increases over time, even in adults. This phenomenon,
known as “neurogenesis”, is associated with neural stem cells present only in the dentate
gyrus of the hippocampus. However, the frequency of neurogenesis is regulated by various
factorsand mastication has been suggested as one such factor. In the present study, we
examined the effects of varying the input of masticatory stimulation on neural stem cells using
feed with different degrees of hardness. Male C57BL/5 mice were used in a comparative
study. After weaning at 3 weeks old, experimental mice were fed a soft or hard diet for 4
or 11 weeks. To study the dynamic behavior of neural stem cells, the expression of two
markers（nestin, a neural stem/progenitor cell marker; and doublecortin, a microtubule-associated protein）was quantitatively analyzed via immunostaining, whereas gene expression was analyzed by real-time polymerase chain reaction （RT-PCR）. Immunostaining-based quantification and gene expression analysis by RT-PCR revealed the decreased expression of markers in the hippocampus in the soft diet group compared to that in the hard diet group. Based on these results, the repression of neurogenesis by a soft diet was associated with changes in neural stem cells in the hippocampus and the frequency of neurogenesis.
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