Nothing directly for us here but our researchers should be able to posit some hypotheses about this helping our brain problems.
http://brainblogger.com/2012/08/24/degenerative-diseases-of-the-brain-new-therapies/
Late onset diseases like Alzheimer’s disease (AD), Parkinson’s
disease (PD) and amyotrophic lateral sclerosis (ALS) are degenerative as
well as progressive and thereby diminish the quality of life of
patients significantly. At present, therapies to treat or reverse
degeneration of brain cells are limited and these diseases usually
progress into disabilities. However, recent research seems to indicate
that it may be possible to limit the damage caused by the onset of AD,
PD and ALS by activating innate biological mechanisms.
A
consequence of the natural respiration process that is always active in
our cells is the production of harmful forms of oxygen, which are known
as reactive oxygen species (ROS). Reactive oxygen species like hydroxyl
ions and hydrogen peroxide are produced in mitochondria. During periods
of wakefulness, our brain consumes 20% of the total oxygen used in the
body and it therefore follows that the chances of generating reactive
oxygen species in brain cells are very high. These highly destructive
molecules are neutralized by two enzyme: heme oxidase-1 (HO-1) and
superoxide dismutase (SOD). In the early stages of AD and PD, the
activity of these enzymes is either normal or reduced. It is surmised
that the capability of the brain to increase the activity of these
antioxidants is diminished in the stages preceding the onset of these
degenerative diseases. In the case of AD, the protein (beta-amyloid
peptide) deposited on nerve cells actually causes an increase in the ROS
within nerve cells.
Recent research suggests that inhalation of
gases like hydrogen, hydrogen sulfide and carbon monoxide, in low and
regulated doses, can actually help to reduce oxidative damage caused by
ROS. Although hydrogen sulfide is toxic, small quantities of this gas
can actually be therapeutic against ROS. A modified form of aspirin
which can release hydrogen sulfide, termed as S-aspirin, is
able to protect brain cells from damage caused by the beta-amyloid
peptide. Similarly, hydrogen, when inhaled, can reach the brain within
an hour and can help to reverse nerve cell damage evident in PD.
Hydrogen can be also given to patients in the form of hydrogen water and
is faster in action than when inhaled in gas form. In experimental
animal models for Parkinson’s disease, treatment with hydrogen water
helped to rescue neurons which respond to dopamine from damage caused by
ROS.
Hydrogen is capable of reacting with hydroxyl radicals to
form water. In addition to this short-term chemical neutralization of
reactive oxygen species, exposure to low doses of hydrogen also causes
enhanced expression of HO-1 and SOD enzymes. Similar effects are also
seen when nerve cells are exposed to carbon monoxide and hydrogen
sulfide. These medical gases boost innate protective responses against
reactive oxygen species and provide long-term protection that goes
beyond immediate and local chemistry in the brain. Exposure of brain
cells to hydrogen sulfide also reduces the amount of beta-amyloid
peptide in nerve cells thereby limiting the damage caused by this
protein.
Since administration of medical gases is a pretty
standard procedure in hospitals and clinics, these scientific advances
may represent a chance of recovery to patients who have been diagnosed
with debilitating diseases like AD, Parkinson’s disease and ALS, at
least in the early stages. The efficiency of these treatments in
patients suffering from advanced stages of these neurodegenerative
diseases is not known yet.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,116 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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