Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 23, 2012

Neocortical neurogenesis and neuronal migration

This is way over my head so ask your researcher to dumb it down to a stroke protocol.
http://onlinelibrary.wiley.com/doi/10.1002/wdev.88/full

INTRODUCTION

A prominent trait of the neocortex is its complex yet well-organized cellular architecture, the formation of which relies on the production and positioning of its diverse neuronal populations. There are two major groups of neurons in the neocortex—glutamatergic excitatory neurons and γ-aminobutyric acid (GABA)-ergic inhibitory interneurons, which are responsible for generating excitation and inhibition, respectively. Excitatory neurons constitute the vast majority (∼70–80%) of neocortical circuit neurons and are responsible for generating the output. On the other hand, inhibitory interneurons provide a rich variety of inhibitions that shape the output of functional circuits. Proper neocortex function critically depends on the production and positioning of a correct number of excitatory and inhibitory neurons, which largely occur during the embryonic stages.
With the advent of improved fate-mapping tools, including genetically engineered mice, excitatory and inhibitory neurons in the neocortex were found to arise from different developmental lineages. In rodents, the progenitor cells of these two neuronal populations are fully segregated in space (Figure 1). Excitatory neurons are generated in the proliferative zone of the dorsal telencephalon and then migrate radially to constitute the future neocortex. In contrast, inhibitory interneurons are produced in the proliferative zone of the ventral telencephalon and migrate tangentially to reach the neocortex, where they coassemble with excitatory neurons into functional circuits. This spatial segregation in the excitatory and inhibitory neuron progenitors no doubt further complicates the coordinated production and positioning of these neurons.

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