http://jnnp.bmj.com/content/83/10/e1.7.abstract
Abstract
Pascal Fries Study of medicine
at the University of Saarland (1991–1993) and at the Johann Wolfgang
von Goethe University
in Frankfurt (1993–1998). Doctorate at
the Max Planck Institute for Brain Research and at the Johann Wolfgang
von Goethe University
in Frankfurt (1993–1999). Postdoc in
the Laboratory of Neuropsychology at the National Institute of Mental
Health, Bethesda,
MD, USA (1999–2001). Principal
Investigator at Donders Institute for Brain, Cognition and Behaviour,
Radboud University, Nijmegen,
Netherlands (2001–2009). Professor of
Systems Neuroscience, Radboud University Nijmegen, Netherlands (since
2008). Scientific
Member of the Max Planck Society,
Director of the Max Planck Institute for Neurobiology, Martinsried, and
Director of the
Ernst Strüngmann Institute (ESI) in
Cooperation with Max Planck Society, Frankfurt (since 2009).
Attention is most likely
implemented by modulations in the effective connectivity among brain
areas. We have proposed that
effective connectivity depends on
rhythmic synchronisation. We have therefore assessed neuronal activity
with 252 electrodes
distributed across one hemisphere
between primary visual cortex and prefrontal cortex. We find that
attention is subserved
by strong and specific enhancements of
interareal synchronisation. The inter-areal influence is often directed,
typically
bottom-up in the gamma-band and
top-down in the β-band. These results suggest that inter-areal
synchronisation subserves effective
inter-areal interactions.
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