Astrocyte roles in traumatic brain injury

What are astrocyte roles in stroke recovery? What did your doctor learn from this to include in your stroke recovery protocols? You could try asking your stroke association to answer the question, but they have no intention of ever tackling anything harder than a press release.
http://www.sciencedirect.com/science/article/pii/S0014488615000898

• Joshua E. Burda,
• Alexander M. Bernstein,
• Michael V. Sofroniew^,

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doi:10.1016/j.expneurol.2015.03.020

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Highlights

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Astrocytes respond to diverse forms of brain injury with heterogeneous and progressive changes of gene expression, morphology, proliferative capacity and function that are collectively referred to as reactive astrogliosis.

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In response to TBI, astrocytes in different cellular microenvironments tune their reactivity to varying degrees of axonal injury, vascular disruption, ischemia and inflammation.

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TBI-reactive astrocytes significantly contribute to post-traumatic tissue repair and synaptic remodeling following brain trauma.

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Abstract

Astrocytes sense changes in neural activity and extracellular space composition. In response, they exert homeostatic mechanisms critical for maintaining neural circuit function, such as buffering neurotransmitters, modulating extracellular osmolarity and calibrating neurovascular coupling. In addition to upholding normal brain activities, astrocytes respond to diverse forms of brain injury with heterogeneous and progressive changes of gene expression, morphology, proliferative capacity and function that are collectively referred to as reactive astrogliosis. Traumatic brain injury (TBI) sets in motion complex events in which noxious mechanical forces cause tissue damage and disrupt central nervous system (CNS) homeostasis, which in turn trigger diverse multi-cellular responses that evolve over time and can lead either to neural repair or secondary cellular injury. In response to TBI, astrocytes in different cellular microenvironments tune their reactivity to varying degrees of axonal injury, vascular disruption, ischemia and inflammation. Here we review different forms of TBI-induced astrocyte reactivity and the functional consequences of these responses for TBI pathobiology. Evidence regarding astrocyte contribution to post-traumatic tissue repair and synaptic remodeling is examined, and the potential for targeting specific aspects of astrogliosis to ameliorate TBI sequelae is considered.