Deans' stroke musings: Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, April 16, 2015

Cardioprotective effect of virgin coconut oil in heated palm oil diet-induced hypertensive rats

But what about for humans? Doctor?
http://informahealthcare.com/doi/abs/10.3109/13880209.2014.971383

Posted online on April 8, 2015. (doi:10.3109/13880209.2014.971383)

Yusof Kamisah, Vengadesh Periyah, Kee Tat Lee, Norrashid Noor-Izwan, Amran Nurul-Hamizah, Badlishah Sham Nurul-Iman, Kogilavani Subermaniam, Kamsiah Jaarin, Abdullah Azman, Othman Faizah, and Hj Mohd Saad Qodriyah

¹Department of Pharmacology, Faculty of Medicine, UKMMC, Universiti Kebangsaan Malaysia,

Kuala Lumpur

, Malaysia,

²Faculty of Dentistry, Universiti Sains Islam Malaysia,

Kuala Lumpur

, Malaysia, and

³Department of Anatomy, Faculty of Medicine, UKMMC, Universiti Kebangsaan Malaysia,

Kuala Lumpur

, Malaysia

*These authors contributed equally to the study.

Correspondence:

Yusof Kamisah, PhD

, Department of Pharmacology, Faculty of Medicine, UKMMC, Universiti Kebangsaan Malaysia,

Jalan Yaacob Latif, 56000 Kuala Lumpur

, Malaysia. Tel: +60 3 91459575. Fax: +60 3 2693 8205. E-mail: kamisah_y@yahoo.com

Abstract

Context: Virgin coconut oil (VCO) contains high antioxidant activity which may have protective effects on the heart in hypertensive rats.
Objectives: The study investigated the effects of VCO on blood pressure and cardiac tissue by measuring angiotensin-converting enzyme (ACE) activity and its histomorphometry in rats fed with a heated palm oil (HPO) diet.
Materials and methods: Thirty-two male Sprague–Dawley rats were randomly divided into four groups: (i) control, (ii) orally given VCO (1.42 ml/kg), (iii) fed with a HPO (15%) diet, and (iv) fed with a HPO diet and supplemented with VCO (1.42 ml/kg, po) (HPO+VCO) for 16 weeks. Blood pressure was measured monthly. After 16 weeks, rat hearts were dissected for lipid peroxidation (TBARS) and ACE activity measurement and histomorphometric study.
Results: Systolic blood pressure was significantly increased in the HPO group compared with the control starting at week eight (112.91 ± 1.32 versus 98.08 ± 3.61 mmHg, p < 0.05) which was prevented by VCO supplementation (91.73 ± 3.42 mmHg). The consumption of HPO increased TBARS and ACE activity in heart, which were inhibited by VCO supplementation. The increases in the myofiber width and area as well as nuclear size reduction in the HPO group were significantly prevented by VCO supplementation.

Conclusion: These results suggested that VCO supplementation possesses a cardioprotective effect by preventing the increase in blood pressure via an antioxidant mechanism and remodeling in rats fed repeatedly with a HPO diet