Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, September 24, 2015

Progranulin protects against the tissue damage of acute ischaemic stroke

What is your doctor going to do with this information? NOTHING? Like all the thousands of other research articles that were ignored? And that doctor still has a job? When are YOU going to demand some accountability?
http://brain.oxfordjournals.org/content/138/7/1770 

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DOI: http://dx.doi.org/10.1093/brain/awv123 1770-1773 First published online: 23 June 2015

This scientific commentary refers to ‘Multiple therapeutic effects of progranulin on experimental acute ischaemic stroke’, by Kanazawa et al. (doi:10.1093/brain/awv079).
Stroke is one of the commonest causes of death, and survivors often suffer debilitating impairments of speech, memory, movement, swallowing and other neurological functions. About 80% of strokes are ischaemic, due to thrombosis or embolism. The resultant loss of oxygen to the affected tissue depletes cells of energy and initiates a series of biological events that include the release of toxic levels of glutamate, the production of free radicals, inflammation, and blood vessel disruption. The infarct, or the region of cell death at the ischaemic core, is surrounded by an area of damaged but still living brain tissue known as the penumbra. The injured but living cells of the penumbra can be restored to functionality if the infarct is prevented from expanding into this region by, for example, restoring blood flow through early administration of the thrombolytic protein tissue plasminogen activator (tPA). Very few other drugs have proven beneficial in limiting stroke-related damage in the human brain (Donnan et al., 2008). The penumbra has been described as a transition zone where processes of cell death and injury radiate outwards from the infarct to confront counteracting mechanisms of repair that are mobilized by the brain to protect the damaged tissue (Lo, 2008). In this issue of Brain, Kanazawa and colleagues provide important insights into how a secreted protein, progranulin, protects the brain from further damage after an ischaemic stroke and suggest that progranulin could be a valuable new weapon in the development of treatments that will protect the brain from stroke-related injury (Kanazawa et al. …

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