Another interesting piece of research needing followup. But that won't occur until we destroy the existing failures of stroke associations. What a
great stroke association would look like.
httpha://europepmc.org/abstract/med/26350339
(PMID:26350339)
Type:
Journal Article
Preclinical
studies have shown that phosphodiesterase inhibitors (PDE-Is) represent
a potential pharmacological strategy for the treatment of
brain ischemia sequelea.
PDE-Is 3, 4 and 5 have been tested in several
brain ischemia
models.
All the three PDE-Is after acute or chronic treatment
decreased the
degree of neurodegeneration and most of them improved functional
recovery after brain injury by specific cellular and molecular
mechanisms mainly involving an anti-inflammatory and/or neuroprotection
action.
In contrast to the large number of investigations using PDE-Is in
experimental
brain ischemia research, the number of clinical studies is still limited.
The purpose of this review is to summarize the data currently available on the effects of PDE-Is in experimental models of
cerebral ischemia.
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