New way to repair nerves

This would be so simple to find out if this works for stroke repair. You ask researchers the cost of the research to prove this one way or the other, then you go to foundations explaining what you are trying to do. Such an innovative proposal should easily shake some money loose. I know grant writers that could do this. Does no one in the stroke world have any BHAGs(Big Hairy Audacious Goals)? I have dozens.

New way to repair nerves

Regenerative medicine using stem cells is an increasingly promising approach to treat many types of injury. Transplanted stem cells can differentiate into just about any other kind of cell, including neurons to potentially reconnect a severed spinal cord and repair paralysis.
A variety of agents have been shown to induce transplanted stem cells to differentiate into neurons.  Tufts Univ. biomedical engineers recently published the first report of a promising new way to induce human mesenchymal stem cells (or hMSCs, which are derived from bone marrow) to differentiate into neuron-like cells: treating them with exosomes.
Exosomes are very small, hollow particles that are secreted from many types of cells. They contain functional proteins and genetic materials and serve as a vehicle for communication between cells. In the nervous system, exosomes guide the direction of nerve growth, control nerve connection and help regenerate peripheral nerves.
In a series of experiments reported in PLOS ONE, the Tufts researchers showed that exosomes from PC12 cells (neuron-like progenitor cells derived from rats) at various stages of their own differentiation could, in turn, cause hMSCs to become neuron-like cells. Exosomes had not previously been studied as a way to induce human stem cell differentiation.
The biomedical engineers also showed that the exosomes contain miRNAs—tiny pieces of RNA that regulate cell behavior and are known to play a role in neuronal differentiation. The researchers hypothesize that the exosomes caused the hMSCs to differentiate by delivering miRNA into the stem cells. The researchers plan future studies to determine the exact mechanism.
Synthetic exosomes could avoid need for neural progenitor cells
"In combination with synthetic nanoparticles that my laboratory is developing, we may ultimately be able to use these identified miRNAs or proteins to make synthetic exosomes, thereby avoiding the need to use any kind of neural progenitor cell line to induce neuron growth," said the paper's senior and corresponding author Qiaobing Xu, assistant professor of biomedical engineering at Tufts School of Engineering.
Source: Tufts Univ.