They talk about eliminating excess cholesterol from the brain, but what problems does that cause since 25% of the cholesterol in your body is found in your brain?
I would ask this of our stroke associations but that would be a waste of time and effort, they don't care about solving any problems in stroke.
http://neurosciencenews.com/tau-cholesterol-alzheimers-2638/
We have known for some years that Alzheimer’s disease is
characterised by two types of lesions, amyloid plaques and degenerated
tau protein. Cholesterol plays an important role in the physiopathology
of this disease. Two French research teams (Inserm/CEA/University of
Lille/University of Paris-Sud ) have just shown, in a rodent model, that
overexpressing an enzyme that can eliminate excess cholesterol from the
brain may have a beneficial action on the tau component of the disease,
and completely correct it. This is the first time that a direct
relationship has been shown between the tau component of Alzheimer’s
disease and cholesterol. This work is published in the 10 September 2015
issue of Human Molecular Genetics.
xcess brain cholesterol cannot freely cross the blood-brain barrier;
to be eliminated it must be converted into 24-hydroxycholesterol
(24-OHC) by the enzyme CYP46A1 (cholesterol-24-hydroxylase). At Inserm
Unit 1169, Nathalie, Cartier, coordinator of this work, and Patrick
Aubourg, director of the unit, proposed the hypothesis that increasing
the efflux of cholesterol from the brain by overexpressing CYP46A1 might
have a beneficial effect on the elements of Alzheimer pathology.
The first step in this work made it possible to show that injecting a
viral vector, AAV-CYP46A1, effectively corrects a mouse model of
amyloid pathology of the disease, the APP23 mouse. CYP46A1 thus appears
to be a therapeutic target for Alzheimer’s disease.
Conversely, in vivo inhibition of CYP46A1 in the mice, using
antisense RNA molecules delivered by an AAV vector administered to the
hippocampus, induces an increase in the production of Aß peptides,
abnormal tau protein, neuronal death and hippocampal atrophy, leading to
memory problems. Together these elements reproduce a phenotype
mimicking Alzheimer’s disease.
These results demonstrate the key role of cholesterol in the disease,
and confirm the relevance of CYP46A1 as a potential therapeutic target
(work published in Brain on 3 July 2015).
Taken together, this work now enables the research team coordinated
by Nathalie Cartier, Inserm Research Director, to propose a gene therapy
approach for Alzheimer’s disease: intracerebral administration of a
vector, AAV-CYP46A1, in patients with early and severe forms (1% of
patients, familial forms) for whom there is no available treatment.
“To achieve this objective, we are carrying out all the preclinical
steps of development and validation of the tools (vector, neurosurgical
protocol, elements of monitoring) for demonstrating the efficacy and
tolerance of the strategy, in order to submit an application for
authorisation of a clinical trial,” explains Nathalie Cartier.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 28,983 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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