Deans' stroke musings: Antidepressant use is associated with an increased risk of developing microbleeds

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 16, 2016

Antidepressant use is associated with an increased risk of developing microbleeds

Well shit, your doctor is going to have to analyze the benefits of antidepressant use in helping your recovery vs. these microbleeds. Does your doctor even know about the positives of antidepressants?
You'll have to ask your doctor why antidepressants were selected as the cause of the microbleeds rather than aspirin or warfarin use or something else entirely. This would seem to be research that was intent on proving something rather than finding the real reason.
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/01/11/antidepressive-agents-cerebral-microbleeds-cerebral-small/6469902/?news_id=881&newsdt=011616&subspec_id=488&utm_source=WeeklyNL&utm_medium=newsletter&utm_content=Weeks-Best-Article&utm_campaign=article-section&category=latest-weekly

Stroke, 01/11/2016 Akoudad S, et al.

In this study, the authors investigated longitudinally whether antidepressant use is associated with an increased risk of new subclinical cerebral microbleeds. Antidepressant use was associated with an increased risk of developing microbleeds. The results may support findings from previous clinical studies about increased intracranial and extracranial bleeding risk in antidepressant users.

Methods

In total, 2559 participants aged ≥45 years of the population-based Rotterdam Study, all without microbleeds at baseline, underwent baseline and repeat brain magnetic resonance imaging between 2005 and 2013 (mean time interval, 3.9 years; SD, 0.5) to determine the incidence of microbleeds.
Antidepressant use (yes versus no) was assessed between baseline and follow-up scan.
In additional analyses, antidepressants were classified as low, intermediate, or high affinity for the serotonin transporter, and alternatively as selective serotonin reuptake inhibitors or non-selective serotonin reuptake inhibitors.
The authors used multivariable logistic regression models to investigate the association of antidepressants with incident microbleeds.

Results

Antidepressant use was associated with a higher cerebral microbleed incidence (odds ratio, 2.22; 95% confidence interval, 1.31-3.76) than nonuse.
When stratified by affinity for the serotonin transporter, intermediate serotonin affinity antidepressant use was associated with an increased risk of developing microbleeds (odds ratio, 3.07; 95% confidence interval, 1.53-6.17).
Finally, selective serotonin reuptake inhibitor and non-selective serotonin reuptake inhibitor use were both associated with increased microbleed incidence.