Deans' stroke musings: The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk.

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, January 16, 2016

The effects of garlic extract upon endothelial function, vascular inflammation, oxidative stress and insulin resistance in adults with type 2 diabetes at high cardiovascular risk.

If we had any strategy at all for stroke this study would be followed up because of endothelial function. But it won't be because we have NO leadership in stroke and fucking failures of stroke associations. Would this work in stroke patients without diabetes?
http://www.mdlinx.com/internal-medicine/medical-news-article/2016/01/08/diabetes-aged-garlic-extract-endothelial-function/6485379/?news_id=387&newsdt=011616&subspec_id=4&utm_source=WeeklyNL&utm_medium=newsletter&utm_content=Weeks-Best-Article&utm_campaign=article-section&category=latest-weekly

Journal of Diabetes and its Complications, 01/08/2016

Atkin M, et al. – This study tested the hypothesis that Aged Garlic Extract (AGE) may improve endothelial function, oxidative stress, vascular inflammation and insulin resistance in high risk cardiovascular subjects with type 2 diabetes. In this group of type 2 diabetic patients at high cardiovascular risk, 4 weeks treatment with AGE did not significantly improve endothelial function, vascular inflammation, oxidative stress or insulin resistance.

Methods

A double blind, placebo controlled cross-over pilot study was performed in 26 subjects with type 2 diabetes who received 1200mg of AGE or placebo daily for 4 weeks with a 4 week washout period.
Plasma HsCRP was measured as a marker of inflammation.
Plasma TAOS,blood GSH/GSSG and plasma LHP were measured as markers of oxidative stress/anti-oxidant defence.
Insulin resistance was measured using the HOMA-IR method.
Endothelial function was measured using change in the reflective index (RI) post salbutamol using digital photoplethysmography and urinary albumin/creatinine ratio was measured as a biochemical surrogate.
Measurements were taken at baseline and after intervention with AGE or placebo.

Results

Of the 26 patients studied (Male 17, Female 9), age was 61 ± 8 yrs (mean ± 1 SD), HbA1c 7.2 ±1.1%, BP 130/75 ±15.9/9.8 mmHg , total cholesterol 4.2 ±0.81mmol/l, triglyceride 2.11 ± 1.51mmol/l, HDL-cholesterol 1.04 ± 0.29mmol/l.
The majority of patients were being treated with metformin (59%), aspirin (50%) and statin (96%) therapy. 36% were treated with an ACEI.
There were no changes in these therapies throughout the study.
Treatment with AGE had no significant effect upon the above metabolic parameters including insulin resistance.
Treatment with AGE also had no significant effect on markers of endothelial function (plethysmography), oxidative stress (TAOS, GSH/GSSG, LHP) or inflammation (HsCRP).