Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, April 9, 2016

Biomaterial applications in cell-based therapy in experimental stroke

You will have to have your doctor read all 35 pages of this to see what might be useful in your recovery.  Some of the statements in there sound incredibly useful.


Biomaterial applications in cell-based therapy in experimental stroke

 

Ligia S.B. BOISSERAND a,b,c, Tomonobu KODAMAd, Jérémie PAPASSINa,b,e, Rachel AUZELYf, Anaïck MOISANg, Claire ROMEa,b, Olivier DETANTEa,b,d,e 
a. Inserm, U1216, BP 170, 38042 Grenoble Cedex 9, France  b. Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France  c. CAPES Foundation, Ministry of Education of Brazil  d. Kyoto University, Institute for Frontier Medical Sciences, Department of Reparative Materials, 606-8507 Kyoto, Japan  e. CHU Grenoble Alpes, Stroke Unit, Department of Neurology, CS 10217, 38043 Grenoble, France  f. Univ. Grenoble Alpes, CERMAV; CNRS, CERMAV, F-38000 Grenoble, France  g. Cell Therapy and Engineering Unit, EFS Rhône Alpes, 464 route de Lancey, 38330 Saint Ismier, France     
Corresponding author: 
Claire ROME
claire.rome@ujf-grenoble.fr
Chemin Fortune Ferrini
Université Grenoble Alpes - Site Santé
BP 170
38042 Grenoble Cedex 9
France      
Keywords: biomaterial, hydrogel, plasticity, neural repair, cell therapy, transplantation, stem cells, stroke. 
Abstract 
Stroke is an important health issue corresponding to the second cause of mortality and first of
severe disability with no effectives treatments after the first hours of onset. Regenerative
approaches such as cell therapy provides an increase in endogenous brain structural plasticity but
not enough to promote a complete recovery. Tissue engineering has recently aroused a major
interesting development of biomaterials for use into the central nervous system. Many
biomaterials have been engineered based on natural compounds, synthetic compounds or a mix
of both with the aim to provide polymers with specific properties. The mechanical properties of
biomaterials can be exquisitely regulated forming polymers with different stiffness, modifiable
physical state that polymerizes in situ or small particles encapsulating cells or growth factors. The
choice of biomaterial compounds should be adapted for the different applications, structure
target and delay of administration. Biocompatibilities with embedded cells and with the host
tissue, and biodegradation rate must be considerate. In this article, we review the different
applications of biomaterials combined with cell therapy in ischemic stroke and we explore specific
features such as choice of biomaterial compounds, physical and mechanical properties concerning
the recent studies in experimental stroke.

 

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