Biomaterial applications in cell-based therapy in experimental stroke

You will have to have your doctor read all 35 pages of this to see what might be useful in your recovery.  Some of the statements in there sound incredibly useful.

Biomaterial applications in cell-based therapy in experimental stroke

 

Ligia S.B. BOISSERAND a,b,c, Tomonobu KODAMAd, Jérémie PAPASSINa,b,e, Rachel AUZELYf, Anaïck MOISANg, Claire ROMEa,b, Olivier DETANTEa,b,d,e 
a. Inserm, U1216, BP 170, 38042 Grenoble Cedex 9, France  b. Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France  c. CAPES Foundation, Ministry of Education of Brazil  d. Kyoto University, Institute for Frontier Medical Sciences, Department of Reparative Materials, 606-8507 Kyoto, Japan  e. CHU Grenoble Alpes, Stroke Unit, Department of Neurology, CS 10217, 38043 Grenoble, France  f. Univ. Grenoble Alpes, CERMAV; CNRS, CERMAV, F-38000 Grenoble, France  g. Cell Therapy and Engineering Unit, EFS Rhône Alpes, 464 route de Lancey, 38330 Saint Ismier, France     
Corresponding author: 
Claire ROME
claire.rome@ujf-grenoble.fr
Chemin Fortune Ferrini
Université Grenoble Alpes - Site Santé
BP 170
38042 Grenoble Cedex 9
France      
Keywords: biomaterial, hydrogel, plasticity, neural repair, cell therapy, transplantation, stem cells, stroke. 
Abstract 
Stroke is an important health issue corresponding to the second cause of mortality and first of
severe disability with no effectives treatments after the first hours of onset. Regenerative
approaches such as cell therapy provides an increase in endogenous brain structural plasticity but
not enough to promote a complete recovery. Tissue engineering has recently aroused a major
interesting development of biomaterials for use into the central nervous system. Many
biomaterials have been engineered based on natural compounds, synthetic compounds or a mix
of both with the aim to provide polymers with specific properties. The mechanical properties of
biomaterials can be exquisitely regulated forming polymers with different stiffness, modifiable
physical state that polymerizes in situ or small particles encapsulating cells or growth factors. The
choice of biomaterial compounds should be adapted for the different applications, structure
target and delay of administration. Biocompatibilities with embedded cells and with the host
tissue, and biodegradation rate must be considerate. In this article, we review the different
applications of biomaterials combined with cell therapy in ischemic stroke and we explore specific
features such as choice of biomaterial compounds, physical and mechanical properties concerning
the recent studies in experimental stroke.