Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, April 6, 2016

Dietary tocotrienol/gamma-cyclodextrin complex increases mitochondrial membrane potential and ATP concentrations in the brain of aged mice

One of the reasons I take tocotrienol. Don't follow me, I know nothing about medicine.

Dietary tocotrienol/gamma-cyclodextrin complex increases mitochondrial membrane potential and ATP concentrations in the brain of aged mice  

Anke Schloesser1, Naoko Ikuta2, Keiji Terao2,3, Seiichi Matsugo4, Gerald Rimbach1* 
1Institute of Human Nutrition and Food Science, University of Kiel, Germany;  2Graduate School of Medicine, Kobe University, Japan;  3Cyclochem Bio Co., Ltd., Kobe, Japan;  4School of Natural System, Kanazawa University, Japan Email*: rimbach@foodsci.uni-kiel.de  
  Brain aging is accompanied by a decline in mitochondrial function. In vitro studies suggest that tocotrienols, including gamma- and delta-tocotrienol (T3), may exhibit neuroprotective properties [1]. However little is known about the effect of dietary T3 on mitochondrial function in vivo. In this study we monitored the effect of a dietary T3/gamma-cyclodextrin complex (T3CD) on mitochondrial membrane potential and ATP levels in the brain (cortex) of 21 month old aged mice. Mice were fed either control diet or a diet enriched with T3CD providing 100 mg T3 per kg diet for 6 months. Dietary T3CD significantly increased mitochondrial membrane potential and ATP levels as compared to controls. The increase of MMP and ATP due to dietary T3CD was accompanied by an increase in the protein levels of the mitochondrial transcription factor A (TFAM). Furthermore dietary T3CD slightly increased mRNA levels of superoxide dismutase, gamma-glutamyl cysteinyl synthetase and heme oxygenase 1 in the brain. Overall, present data suggest that T3CD increases TFAM, mitochondrial membrane potential and ATP synthesis in the brain of aged mice.

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