Deans' stroke musings: Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson's disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, April 6, 2016

Transplantation of human umbilical cord blood-derived mononuclear cells induces recovery of motor dysfunction in a rat model of Parkinson's disease

If we had any stroke leadership or strategy this research would be followed up to see if it would help stroke survivors. But we have neither because we have fucking failures of stroke associations. You're screwed, your children will be screwed, your grandchildren will be screwed unless we destroy and start over the stroke associations. Storm the castles.
https://www.dovepress.com/articles.php?article_id=26279

Authors Chen C, Duan J, Shen A, Wang W, Song H, Liu Y, Lu X, Wang X, You Z, Han Z, Han F
Received 21 October 2015
Accepted for publication 4 December 2015
Published 4 April 2016 Volume 2016:4 Pages 23—33
DOI http://dx.doi.org/10.2147/JN.S98835
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Tajinder Dhammu
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Hari Shanker Sharma

Chao Chen,^1,* Jing Duan,^1,*Aifang Shen,^2,* Wei Wang,¹ Hao Song,¹ Yanming Liu,¹ Xianjie Lu,¹Xiaobing Wang,² Zhiqing You,¹ Zhongchao Han,^3,4 Fabin Han¹

¹Center for Stem Cells and Regenerative Medicine, The Liaocheng People's Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People's Republic of China; ²Department of Gynecology and Obstetrics, The Liaocheng People's Hospital, Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People's Republic of China; ³The State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences, Peking Union of Medical College, Tianjin, People's Republic of China; ⁴National Engineering Research Center of Cell Products, AmCellGene Co. Ltd., TEDA, Tianjin, People's Republic of China

*These authors contributed equally to this work

Abstract: Human umbilical cord blood-derived mononuclear cells (hUCB-MNCs) were reported to have neurorestorative capacity for neurological disorders such as stroke and traumatic brain injury. This study was performed to explore if hUCB-MNC transplantation plays any therapeutic effects for Parkinson's disease (PD) in a 6-OHDA-lesioned rat model of PD. hUCB-MNCs were isolated from umbilical cord blood and administered to the striatum of the 6-OHDA-lesioned rats. The apomorphine-induced locomotive turning-overs were measured to evaluate the improvement of motor dysfunctions of the rats after administration of hUCB-MNCs. We observed that transplanted hUCB-MNCs significantly improve the motor deficits of the PD rats and that grafted hUCB-MNCs integrated to the host brains and differentiated to neurons and dopamine neurons in vivo after 16 weeks of transplantation. Our study provided evidence that transplanted hUCB-MNCs play therapeutic effects in a rat PD model by differentiating to neurons and dopamine neurons.