Would this help in the inflammatory effects post stroke and the inflammation in the arteries resulting in plaque?
If we had ANY stroke leadership or strategy this research would be
followed up to see if it would help stroke survivors. But we have
neither because we have fucking failures of stroke associations. You're
screwed, your children will be screwed, your grandchildren will be
screwed unless we destroy and start over the stroke associations. Storm
the castles.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=162830&CultureCode=en
For an innovative treatment, which allows to selectively direct
nanoparticles of iron oxide into cell targets in the blood to fight
chronic inflammatory disorders or cancer that was successfully tested in
a cell culture and animal models, Dr. Andrea de Vizcaya Ruiz, was
awarded with the Innovation Award in Bionanotechnology
Cinvestav-Neolpharma 2015.
The research suggests that it is possible to use a group of proteins
present in blood plasma (liquid portion of the blood) as carrier
vehicles of iron nanoparticles to direct them towards a group of cells
known as macrophages that belong to the immune system.
Vizcaya Ruiz, who is also coordinator of the Department of Toxicology
Research Center for Advanced Studies (CINVESTAV), performed this work
with doctoral student Vicente Escamilla Rivera.
During the research they found that when introducing iron
nanoparticles in a biological media such as blood, its surface is
immediately covered by a layer of biomolecules known as a "crown
protein".
Vizcaya evaluated whether this interaction could be used to guide the
nanoparticles to organs rich in macrophages using proteins from the
complement system, which is one of the vital parts of the immune system
response to the entry of invaders.
They used three kinds of nanoparticles of iron oxide: two of them
were coated with polymers (polyethylene glycol and polyvinylpyrrolidone)
and the other had no coating. The team found that the interaction
between these and the blood plasma proteins favors the accumulation of
macrophages.
In addition, their in vitro tests found that the biocompatibility was
higher when using nanoparticles coated with polyethylene glycol, which
helped to make more efficient and with fewer side effects the
anti-cancer therapies. Furthermore, with the coating formed by the crown
protein toxicity was reduced.
Subsequently, they used an experimental model in animals and found
that by attracting and retaining proteins of the complementary system,
the nanoparticles accumulated mostly in organs rich in macrophages, such
as the liver and spleen, additional to inducing the activation of the
immune system.
The discovery of Vizcaya could be applied in future human clinical
trials; for example, in the design of nanoparticles containing
activators of the above proteins of the complementary system, so they
can directly strike the desired cell target.
Also, the immune system activation induced by the nanoparticles
coated with polyethylene glycol may be used in addition to stimulating
the host's response to infectious diseases.
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