I can't tell what this is supposed to suggest. Translate rat time to human time and don't start therapy until after that?
http://linkinghub.elsevier.com/retrieve/pii/S0006899316305388?via=sd
Abstract
Introduction
Although physical exercise has emerged as a potential therapeutic
modality for functional deficits following ischemic stroke, the extent
of this effect appears to be contingent upon the time of exercise
initiation. In the present study, we assessed how exercise timing
affected brain damage through hyperglycolysis-associated NADPH oxidase
(NOX) activation.
Methods
Using an intraluminal filament, adult male Sprague-Dawley rats were
subjected to middle cerebral artery occlusion (MCAO) for 2h and assigned
to one non-exercise and three exercise groups. Exercise on Rota-rod was
initiated for 30min at 6h (considered very early), at 24h (early), and
at day 3 (relatively late) after reperfusion. Lactate production was
measured 30min after exercise completion, and NOX activity and protein
expression of NOX subunits (p47phox, gp91phox, p22phox and p67phox) and
glucose transporter 1 and 3 (Glut-1 and −3) were measured at 3 and 24h
after exercise. Apoptotic cell death was determined at 24h after
exercise.
Results
Lactate production and Glut-1 and Glut-3 expression were increased
after very early exercise (6h), but not after late exercise (3 days),
suggesting hyperglycolysis. NOX activity was increased with the
initiation of exercise at 6h (P<0.05), but not 24h or 3 days,
following stroke. Early (6 and 24h), but not late (3 days), post-stroke
exercise was associated with increased (P<0.05) expression of the NOX
protein subunit p47phox, gp91phoxand p67phox. This may have led to
enhanced apoptosis after early exercise in ischemic rats.
Conclusion
Hyperglycolysis and NOX activation was associated with an elevation
in apoptotic cell death after very early exercise, and the detrimental
effect of exercise on stroke recovery began to decrease when exercise
was initiated 24h after reperfusion.
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