Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Saturday, August 6, 2016

Neuroplasticity after Sexual Experience in the Nucleus Accumbens of Syrian hamsters

How is your doctor going to relate this needed neuroplasticity into stroke protocols?
http://thesis.haverford.edu/dspace/handle/10066/18751

Author: Acabá, Luis
Advisor: Been, Laura
Department: Haverford College. Department of Psychology
Type: Thesis
Issue Date: 2016
Abstract: Research over the past three decades has demonstrated that many neural changes occur in response to rewarding stimuli and behavior. However, most of this research has focused on the changes that occur following drug use and their role in addiction. Less research has investigated the neural changes in response to everyday rewarding behaviors such as eating, exercising, and sexual behavior, and even less has explored whether these changes differ in male and female brains. The goal of this study was to investigate the changes in brain circuitry that occur in Syrian hamsters after exposure to sexual experiences and to identify any possible sex differences involved. Specifically, levels of delta FosB, a transcription factor that is important for long-term neural plasticity following rewarding experiences, was measured in the Nucleus Accumbens (NAc) as a way to quantify these neural changes. This study also aimed at investigating whether the efficiency with which hamsters mate is improved with experience, as measured by the time the hamsters are actively having sex and the amount of sex-related behaviors they perform. It was expected that sexual experiences would lead to an up-regulation of delta FosB in the NAc, that this up-regulation would not differ between the sexes, and that mating efficiency would improve with experience. The results demonstrated that sexual experience led to higher delta FosB levels in the NAc than controls, and that there were no differences in delta FosB levels between males and females of the same group. This study also found that mating efficiency was not improved with experience. The results obtained in this study suggest that the normal rewarding behavior of sexual experience leads to neuroplastic changes in the NAc of Syrian hamsters and that male and female Syrian hamsters likely have similar neuroplastic changes following sexual experiences. This research has the potential to provide a better understanding of how drugs of abuse take advantage of reward pathways, and eventually lead to better treatments for addiction.
Terms of Use: https://creativecommons.org/licenses/by/4.0/
Permanent URL: http://hdl.handle.net/10066/18751

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2016AcabaL.pdf Thesis 666.0Kb PDF
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Citation

Acabá, Luis. "Neuroplasticity after Sexual Experience in the Nucleus Accumbens of Syrian hamsters". 2016. Available electronically from http://hdl.handle.net/10066/18751.

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