I bet this will never make it to human clinical trials because we have
fucking failures of stroke associations who don't know how to raise money to run trials like these. And stroke survivors become victims once again because of that incompetence. You get what YOU speak up for. Contact your stroke association president and ask how come they are so fucking bad at their job. Their job is to make things better for survivors, not stand in the way.
http://journal.frontiersin.org/article/10.3389/fnagi.2016.00124/full?
- Translational Stroke Research Laboratory, Faculty of
Health and Medicine, School of Biomedical Sciences and Pharmacy, Hunter
Medical Research Institute and The University of Newcastle, Callaghan,
NSW, Australia
Stroke is predominantly a senescent disease, yet most preclinical
studies investigate treatment in young animals. We recently demonstrated
that short-duration hypothermia-treatment completely prevented the
dramatic intracranial pressure (ICP) rise seen post-stroke in young
rats. Here, our aim was to investigate whether a similar ICP rise occurs
in aged rats and to determine whether short-duration hypothermia is an
effective treatment in aged animals. Experimental middle cerebral artery
occlusion (MCAo-3 h occlusion) was performed on male Wistar rats aged
19–20 months. At 1 h after stroke-onset, rats were randomized to 2.5 h
hypothermia-treatment (32.5°C) or normothermia (37°C). ICP was monitored
at baseline, for 3.5 h post-occlusion, and at 24 h post-stroke. Infarct
and edema volumes were calculated from histology. Baseline pre-stroke
ICP was 11.2 ± 3.3 mmHg across all animals. Twenty-four hours
post-stroke, ICP was significantly higher in normothermic animals
compared to hypothermia-treated animals (27.4 ± 18.2 mmHg vs. 8.0 ± 5.0
mmHg,
p = 0.03). Infarct and edema volumes were not significantly
different between groups. These data demonstrate ICP may also increase
24 h post-stroke in aged rats, and that short-duration hypothermia
treatment has a profound and sustained preventative effect. These
findings may have important implications for the use of hypothermia in
clinical trials of aged stroke patients.
Introduction
Age is the most important independent non-modifiable risk
factor for ischemic stroke, and with an aging population, the burden of
stroke is expected to increase dramatically. The difficulty, expense
and mortality rate in older animals has resulted in very few aged animal
stroke studies being conducted, despite the STAIR criteria suggesting
the use of aged animals following initial evaluations in young and
healthy animals (
Fisher et al., 2009). Such testing is a key part of the strategy for successful translation from bench to bedside (
O’Collins et al., 2006).
Previous investigations by our group have demonstrated that early
treatment with short-duration hypothermia has a preventative effect on
intracranial pressure (ICP) elevation, 24 h post-stroke in young rats (
Murtha et al., 2014a,
2015).
In this short report we aimed to: (1) Determine whether ICP elevation
occurred post-stroke in aged rats, and (2) Determine whether a short
duration of hypothermia treatment prevented this ICP elevation
post-stroke in aged rats.
More at link.
Lucy A. Murtha, 
Daniel J. Beard, 
Neil J. Spratt*
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