Deans' stroke musings

Changing stroke rehab and research worldwide now.Time is Brain!Just think of all the trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 493 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It's quite disgusting that this information is not available from every stroke association and doctors group.
My back ground story is here:http://oc1dean.blogspot.com/2010/11/my-background-story_8.html

Monday, August 8, 2016

Intracranial Pressure Elevation 24 h after Ischemic Stroke in Aged Rats Is Prevented by Early, Short Hypothermia Treatment

I bet this will never make it to human clinical trials because we have fucking failures of stroke associations who don't know how to raise money to run trials like these. And stroke survivors become victims once again because of that incompetence. You get what YOU speak up for. Contact your stroke association president and ask how come they are so fucking bad at their job. Their job is to make things better for survivors, not stand in the way.
http://journal.frontiersin.org/article/10.3389/fnagi.2016.00124/full?

Lucy A. Murtha, Daniel J. Beard, Julia T. Bourke, Debbie Pepperall, Damian D. McLeod and Neil J. Spratt*
  • Translational Stroke Research Laboratory, Faculty of Health and Medicine, School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute and The University of Newcastle, Callaghan, NSW, Australia
Stroke is predominantly a senescent disease, yet most preclinical studies investigate treatment in young animals. We recently demonstrated that short-duration hypothermia-treatment completely prevented the dramatic intracranial pressure (ICP) rise seen post-stroke in young rats. Here, our aim was to investigate whether a similar ICP rise occurs in aged rats and to determine whether short-duration hypothermia is an effective treatment in aged animals. Experimental middle cerebral artery occlusion (MCAo-3 h occlusion) was performed on male Wistar rats aged 19–20 months. At 1 h after stroke-onset, rats were randomized to 2.5 h hypothermia-treatment (32.5°C) or normothermia (37°C). ICP was monitored at baseline, for 3.5 h post-occlusion, and at 24 h post-stroke. Infarct and edema volumes were calculated from histology. Baseline pre-stroke ICP was 11.2 ± 3.3 mmHg across all animals. Twenty-four hours post-stroke, ICP was significantly higher in normothermic animals compared to hypothermia-treated animals (27.4 ± 18.2 mmHg vs. 8.0 ± 5.0 mmHg, p = 0.03). Infarct and edema volumes were not significantly different between groups. These data demonstrate ICP may also increase 24 h post-stroke in aged rats, and that short-duration hypothermia treatment has a profound and sustained preventative effect. These findings may have important implications for the use of hypothermia in clinical trials of aged stroke patients.

Introduction

Age is the most important independent non-modifiable risk factor for ischemic stroke, and with an aging population, the burden of stroke is expected to increase dramatically. The difficulty, expense and mortality rate in older animals has resulted in very few aged animal stroke studies being conducted, despite the STAIR criteria suggesting the use of aged animals following initial evaluations in young and healthy animals (Fisher et al., 2009). Such testing is a key part of the strategy for successful translation from bench to bedside (O’Collins et al., 2006). Previous investigations by our group have demonstrated that early treatment with short-duration hypothermia has a preventative effect on intracranial pressure (ICP) elevation, 24 h post-stroke in young rats (Murtha et al., 2014a, 2015). In this short report we aimed to: (1) Determine whether ICP elevation occurred post-stroke in aged rats, and (2) Determine whether a short duration of hypothermia treatment prevented this ICP elevation post-stroke in aged rats.

More at link.

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