Deans' stroke musings: Plasma matrix metalloproteinases in patients with stroke during intensive rehabilitation therapy

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, December 15, 2016

Plasma matrix metalloproteinases in patients with stroke during intensive rehabilitation therapy

I don't see what possible use knowing these levels are could be helpful in your stroke recovery. So go ask your doctor.
http://search.naric.com/research/rehab/redesign_record.cfm?search=2&type=all&criteria=J74751&phrase=no&rec=132004&article_source=Rehab&international=0&international_language=&international_location=
Archives of Physical Medicine and Rehabilitation , Volume 97(11) , Pgs. 1832-1840.

NARIC Accession Number: J74751. What's this?
ISSN: 0003-9993.
Author(s): Ma, Feifei; Rodriguez, Susana; Buxo, Xavi; Morancho, Anna; Riba-Llena, Iolanda; Carrera, Ana; Bustamante, Alejandro; Giralt, Dolors; Montaner, Joan; Martinez, Carmen; Bori, Immaculada; Rosell, Anna.
Publication Year: 2016.
Number of Pages: 9.
Abstract: Study investigated plasma levels of matrix metalloproteinases (MMPs) as potential markers of recovery during intensive rehabilitation therapy (IRT) after stroke. The primary purpose was to measure plasma MMP3, MMP12, and MMP13 levels and evaluate potential associations with motor/functional scales using a battery of tests before IRT and at 1- and 3-month follow-ups. The secondary aim was to evaluate the use of these MMPs as biomarkers as predictors of patient’s outcome. Fifteen patients with first-ever ischemic stroke enrolled tin IRT (minimum 3 hours per day and 5 days a week) and 15 healthy volunteers were evaluated. Results showed that MMP levels remained stable during the study period and were similar to those in the healthy volunteer group. However, baseline MMP12 and MMP13 levels were strongly associated with stroke severity and were found to be elevated in those patients with the poorest outcomes. Interestingly, plasma MMP3 was independent of baseline stroke characteristics but was found to be increased in patients with better motor/functional recovery and in patients with larger improvements during rehabilitation. Findings suggest that MMPs might act as biologic markers of recovery during rehabilitation therapy related to their roles in both injury and tissue remodeling. Future confirmatory investigations in multicenter studies are warranted.