https://www.sciencedirect.com/science/article/pii/S1388245718305170
Introduction
The
non-injured, contralateral hemisphere is increasingly acknowledged in
recovery from acute ischemic stroke. We estimate the value of
conventional EEG recordings for identification of contralateral
hemisphere involvement in relation to functional recovery.
Methods
We
analyzed two-minute epochs from 21 electrode EEG registrations from 18
patients with acute hemispheric ischemic stroke and compared with 18
age-matched controls. Outcome was dichotomized as good (mRS 0–2) or poor
(mRS 3–5 or death) at three months. Effects of the infarct on the ipsi-
and contralateral hemispheres were analyzed by the delta/alpha ratio
(DAR) and two measures of functional connectivity (magnitude squared
coherence (MSC) and weighted phase lag index (WPLI)).
Results
DAR
was higher in patients than in controls, both in the ipsilateral and in
the contralateral hemisphere (median 4.5 ± 6.7 ipsilateral and
2.4 ± 2.0 contralateral vs. 0.5 ± 0.5 in the control group, P < 0.001),
indicating robust EEG changes in both lesioned and non-lesioned
hemisphere. MSC and WPLI in the alpha and beta frequency bands were
lower in patients than in controls in both hemispheres, indicating clear
disturbances of functional connectivity (P < 0.05). In the
poor outcome group, contralateral MSC and WPLI were lower than in the
good outcome group, although these differences did not reach statistical
significance.
Conclusion
Short
conventional EEG measurements show robust changes of brain activity and
functional connectivity in both ipsilateral and contralateral hemisphere
of patients with acute ischemic stroke. Changes of remote functional
connectivity tend to interact with functional recovery. Associations
between contralateral functional connectivity measures and incidence of
apathy and depression are currently analyzed and will be presented.
Choose an option to locate/access this article:
Check if you have access through your login credentials or your institution
Check Access
No comments:
Post a Comment