Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, May 27, 2018

Postmortem Brain MRI Is Related to Cognitive Decline, Independent of Cerebral Vessel Disease in Older Adults

I sure as hell hope that my doctors can figure out any cognitive decline reasons and correct them  before I'm autopsied.
https://www.sciencedirect.com/science/article/pii/S019745801830188X


Highlights

Postmortem MRI transverse relaxation (R2) is associated with the linear rate of global cognitive decline in late life and accounts for more than 5% of its variance.
The association of R2 with cognitive decline persists after accounting for indices of cerebral vessel disease, namely atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy.
R2 is also associated with specific components of a nonlinear model of cognitive decline.
R2 reflects a dimension of brain tissue integrity not captured by current histopathologic indices and therefore may highlight important targets for future interventions against late life cognitive decline.

ABSTRACT

The purpose of this study was to determine whether metrics of brain tissue integrity derived from postmortem MRI are associated with late life cognitive decline, independent of cerebral vessel disease. Using data from 554 older adults, we employed voxelwise regression to identify regions where the postmortem MRI transverse relaxation rate constant R2 was associated with the rate of decline in global cognition. We then used linear mixed models to investigate the association between a composite R2 measure and cognitive decline, controlling for neuropathology including three indices of vessel disease: atherosclerosis, arteriolosclerosis, and cerebral amyloid angiopathy. This composite R2 measure was associated with the rate of decline (0.049 unit annually per R2 unit, p<0.0001) and accounted for 6.1% of its variance, beyond contributions from vessel disease indices and other prominent age-related neuropathologies. Thus, postmortem brain R2 reflects disease processes underlying cognitive decline that are not captured by vessel disease indices or other standard neuropathologic indices and may provide a measure of brain tissue integrity that is complementary to histopathologic evaluation.

Keywords

  • Transverse relaxation;
  • R2;
  • voxelwise;
  • atherosclerosis;
  • arteriolosclerosis;
  • cerebral amyloid angiopathy
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