Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, May 30, 2018

Researchers Create Advanced Brain Organoid to Model Strokes, Screen Drugs

Which built brain should our researchers be using? I expect our researchers to be using the best one.

Nearly complete human brain grown in US lab: scientist.

Multiregional brain on a chip  Jan 2017


Draper Laboratory developing “Brain-on-a-Chip”  October 2012


"Alzheimer's-in-a-Dish" Docs Win Top Smithsonian Ingenuity Award Nov. 2015 

A patient’s budding cortex — in a dish?  June 2015 


Cell cultures in petri dishes open new doors to brain research  April 2017


Researchers Create Advanced Brain Organoid to Model Strokes, Screen Drugs


Wake Forest Institute for Regenerative Medicine (WFIRM) scientists have developed a 3-D brain organoid that could have potential applications in drug discovery and disease modeling. This is the first engineered tissue equivalent to closely resemble normal human brain anatomy, containing all six major cell types found in normal organs including, neurons and immune cells.
In a study published this month in Scientific Reports, the researchers report that their advanced 3-D organoids promote the formation of a fully cell-based, natural and functional barrier - the blood brain barrier - that mimics normal human anatomy.
The blood brain barrier is a semipermeable membrane that separates the circulating blood from the brain, protecting it from foreign substances that could cause injury. This development is important because the model can help to further understanding of disease mechanisms at the blood brain barrier, the passage of drugs through the barrier, and the effects of drugs once they cross the barrier.
"The shortage of effective therapies and low success rate of investigational drugs are due in part because we do not have a human-like tissue models for testing," said senior author Anthony Atala, M.D., director of WFIRM. "The development of tissue engineered 3D brain tissue equivalents such as these can help advance the science toward better treatments and improve patients' lives."
The development of the model opens the door to speedier drug discovery and screening, both for neurological conditions and for diseases like HIV where pathogens hide in the brain and avoid current treatments that cannot cross the blood brain barrier. It may also allow for disease modeling of neurological conditions such as Alzheimer's disease, multiple sclerosis and Parkinson's disease so that researchers can better understand their pathways and progression.
Thus far the researchers have used the brain organoids to mimic strokes in order to measure impairment of the blood brain barrier and have successfully tested the model's permeability with large and small molecules.
"Using an engineered tissue model provides a platform that can be used to understand the fundamental principles at play with the blood brain barrier and its function, as well as the effects of chemical substances that cross it," said Goodwell Nzou, a Ph.D. candidate at WFIRM who co-authored the paper.

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