An ingestible bacterial-electronic system to monitor gastrointestinal health

With any brains at all amongst our stroke medical professionals we could use this to determine the exact diet needed for optimum brain health using the gut-brain axis. But that won't occur because we have fucking failures of stroke associations.
23 posts on gut bacteria.
5 posts on gut microbes.
7 posts on gut microbiome.
3 posts on gut microbiota.
Even with all this information on gut-brain axis nothing will be done by your stroke medical professionals.


http://science.sciencemag.org/content/360/6391/915

1. Mark Mimee¹,²,*,
2. Phillip Nadeau³,*,†,
3. Alison Hayward⁴,⁵,
4. Sean Carim²,
5. Sarah Flanagan³,
6. Logan Jerger²,⁶,⁷,
7. Joy Collins⁵,
8. Shane McDonnell⁵,
9. Richard Swartwout³,
10. Robert J. Citorik¹,²,
11. Vladimir Bulović³,
12. Robert Langer⁵,⁸,
13. Giovanni Traverso⁵,⁸,⁹,
14. Anantha P. Chandrakasan³,‡,
15. Timothy K. Lu²,³,¹⁰,‡

1. ¹Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
2. ²Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.
3. ³Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
4. ⁴Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA.
5. ⁵Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.
6. ⁶Division of Pediatric Gastroentrology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA 02114, USA.
7. ⁷Harvard Medical School, Boston, MA 02115, USA.
8. ⁸Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.
9. ⁹Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
10. ¹⁰Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

1. ↵‡Corresponding author. Email: timlu@mit.edu (T.K.L.); anantha@mtl.mit.edu (A.P.C.)

1. ↵* These authors contributed equally to this work.
2. ↵† Present address: Analog Devices, Boston, MA 02110, USA.

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Science  25 May 2018:
Vol. 360, Issue 6391, pp. 915-918
DOI: 10.1126/science.aas9315

Mark Mimee

Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

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Phillip Nadeau

Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

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Alison Hayward

Division of Comparative Medicine, MIT, Cambridge, MA 02139, USA.Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

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Sean Carim

Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

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Sarah Flanagan

Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

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Logan Jerger

Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.Division of Pediatric Gastroentrology, Hepatology, and Nutrition, Department of Pediatrics, MassGeneral Hospital for Children, Boston, MA 02114, USA.Harvard Medical School, Boston, MA 02115, USA.

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Joy Collins

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

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Shane McDonnell

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.

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Richard Swartwout

Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

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Robert J. Citorik

Microbiology Program, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.

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Vladimir Bulović

Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

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Robert Langer

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.

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Giovanni Traverso

Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA.Department of Chemical Engineering, MIT, Cambridge, MA 02139, USA.Division of Gastroenterology, Brigham and Women’s Hospital, Boston, MA 02115, USA.

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Anantha P. Chandrakasan

Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.

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• For correspondence: timlu@mit.eduanantha@mtl.mit.edu

Timothy K. Lu

Synthetic Biology Center, MIT, Cambridge, MA 02139, USA.Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.

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• For correspondence: timlu@mit.eduanantha@mtl.mit.edu

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Abstract

Biomolecular monitoring in the gastrointestinal tract could offer rapid, precise disease detection and management but is impeded by access to the remote and complex environment. Here, we present an ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device. As a proof of concept, we engineer heme-sensitive probiotic biosensors and demonstrate accurate diagnosis of gastrointestinal bleeding in swine. Additionally, we integrate alternative biosensors to demonstrate modularity and extensibility of the detection platform. IMBEDs enable new opportunities for gastrointestinal biomarker discovery and could transform the management and diagnosis of gastrointestinal disease.

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