Deans' stroke musings: Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 11, 2019

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Sounds promising for your very likely chance of dementia. Next steps?

Has your stroke doctor and hospital done ONE DAMN THING to initiate further research? Or it is not their responsibility?

Are your doctor and stroke hospital being responsible and doing any followup to get research going?

Our fucking failures of stroke associations will DO NOTHING. Your doctor will DO NOTHING. Your stroke hospital will DO NOTHING. You're screwed.

Or will NOTHING BE DONE since everyone in stroke is

waiting for SOMEONE ELSE TO SOLVE THE PROBLEM?

And why are they doing nothing?

Laziness? Incompetence? Or just don't care? No leadership? No strategy? Not my job? The board of directors didn't tell them that totally solving stroke was their job, not just lazily relying on the status quo?

https://doi.org/10.1016/j.neuron.2019.04.011 Get rights and content

Highlights

•: 40-Hz visual stimulation entrains gamma oscillations in V1, CA1, and PFC
•: GENUS reduces neuronal and synaptic loss in mouse models of neurodegeneration
•: GENUS modifies synaptic signaling and synaptic-plasticity-related proteins
•: GENUS improves spatial learning and memory in Tau P301S and CK-p25 mice

Summary

Neuronal and synaptic loss is characteristic in many neurodegenerative diseases, such as frontotemporal dementia and Alzheimer’s disease. Recently, we showed that inducing gamma oscillations with visual stimulation (gamma entrainment using sensory stimuli, or GENUS) reduced amyloid plaques and phosphorylated tau in multiple mouse models. Whether GENUS can affect neurodegeneration or cognitive performance remains unknown. Here, we demonstrate that GENUS can entrain gamma oscillations in the visual cortex, hippocampus, and prefrontal cortex in Tau P301S and CK-p25 mouse models of neurodegeneration. Tau P301S and CK-p25 mice subjected to chronic, daily GENUS from the early stages of neurodegeneration showed a preservation of neuronal and synaptic density across multiple brain areas and modified cognitive performance. Our transcriptomic and phosphoproteomic data suggest that chronic GENUS shifts neurons to a less degenerative state, improving synaptic function, enhancing neuroprotective factors, and reducing DNA damage in neurons while also reducing inflammatory response in microglia.

Graphical Abstract

⁸: These authors contributed equally

⁹: Lead Contact

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Neuron, 2019

Deans' stroke musings