Deans' stroke musings: Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, May 11, 2019

Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches

Useless piece of crap. Nothing here will help survivors recover. You should all be fired.

Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches

Mensen A¹, Pigorini A², Facchin L³, Schöne C³, D'Ambrosio S², Jendoubi J³, Jaramillo V⁴, Chiffi K³, Eberhard-Moscicka AK³, Sarasso S², Adamantidis A³, Müri RM³, Huber R⁴, Massimini M², Bassetti C³.

Author information

Erratum in

Corrigendum to: "Sleep as a model to understand neuroplasticity and recovery after stroke: Observational, perturbational and interventional approaches" [Journal of Neuroscience Methods Volume 313, 1 February 2019, Pages 37-43]. [J Neurosci Methods. 2019]

Abstract

Our own experiences with disturbances to sleep demonstrate its crucial role in the recovery of cognitive functions. This importance is likely enhanced in the recovery from stroke; both in terms of its physiology and cognitive abilities. Decades of experimental research have highlighted which aspects and mechanisms of sleep are likely to underlie these forms of recovery. Conversely, damage to certain areas of the brain, as well as the indirect effects of stroke, may disrupt sleep. However, only limited research has been conducted which seeks to directly explore this bidirectional link between both the macro and micro-architecture of sleep and stroke. Here we describe a series of semi-independent approaches that aim to establish this link through observational, perturbational, and interventional experiments. Our primary aim is to describe the methodology for future clinical and translational research needed(So you want someone else to do the actual hard work of solving this? Too hard for you? Not your job?) to delineate competing accounts of the current data. At the observational level we suggest the use of high-density EEG recording, combined analysis of macro and micro-architecture of sleep, detailed analysis of the stroke lesion, and sensitive measures of functional recovery. The perturbational approach attempts to find the causal links between sleep and stroke. We promote the use of transcranial magnetic stimulation combined with EEG to examine the cortical dynamics of the peri-infarct stroke area. Translational research should take this a step further using optogenetic techniques targeting more specific cell populations. The interventional approach focuses on how the same clinical and translational perturbational techniques can be adapted to influence long-term recovery of function.