Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients

So you described an inflammation problem but did nothing  to prevent or reduce that problem.  Useless, but do suggest further research.

Residual Inflammatory Risk Predicts Poor Prognosis in Acute Ischemic Stroke or Transient Ischemic Attack Patients

 

Li and colleagues studied the relation of low-density cholesterol and hs-CRP (high-sensitive C-reactive protein) levels and risk of recurrent ischemic stroke, cardiovascular events (all stroke, myocardial infarction, vascular death), and cardiovascular death. The study was a multicenter study conducted in China, including 11 261 patients with acute ischemic stroke or transient ischemic attack. Patients were grouped into 4 groups: elevated baseline cholesterol and hs-CRP levels, cholesterol at target but high hs-CRP level, high cholesterol but normal hs-CRP, cholesterol levels at target and normal hs-CRP. In cox regression analyses adjusted for baseline confounders, patients with high hs-CRP level, and those with high elevation of both low-density cholesterol and hs-CRP had higher risk of recurrent stroke. The associations were mainly in patients with large artery or cardioembolic stroke mechanisms. Patients in the same groups were more likely to have modified Rankin Scale scores ≥2 at 1 year. Similar associations were observed with composite cardiovascular events but not with death. In patients with cholesterol levels at target on presentation and at 3 months follow-up, higher hs-CRP was associated with higher risk of disability, recurrent stroke, and composite cardiovascular events. This study suggests a role for inflammation in recurrent stroke, and potential patient subgroups that could be included in randomized clinical trials evaluating inflammation as treatment target to reduce recurrent stroke risk. See p 2827.