Deans' stroke musings: Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, September 26, 2021

Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review

All this research did was to suggest more research is needed, so this research was a total failure.

Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review

Archives of Physical Medicine and Rehabilitation , Volume 102(8) , Pgs. 1633-1644.

NARIC Accession Number: J87026. What's this?
ISSN: 0003-9993.
Author(s): Limaye, Neeraj S. ; Carvalho, Lilian B. ; Kramer, Sharon.
Publication Year: 2021.
Number of Pages: 12.

Abstract:

Study summarized the evidence for the effects of aerobic exercise (AE) on serum biomarkers neuroplasticity and brain repair in survivors of stroke. MEDLINE, Embase, and Cochrane CENTRAL databases were searched for relevant studies using terms related to AE, neuroplasticity, brain repair, and stroke. Titles, abstracts, and selected full texts were screened by 2 independent reviewers against the following inclusion criteria: including adult survivors of stroke, completing an AE intervention working within the AE capacity, and measuring at least 1 blood biomarker outcome of interest. Two independent reviewers extracted data and assessed risk of bias using Risk of Bias in Nonrandomized Studies of Interventions and Cochrane’s Risk of Bias 2 tools. Nine studies were included, reporting on the following outcomes: brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), cortisol, interleukin 6, and myeloperoxidase. A single bout of high-intensity interval training significantly increased BDNF, IGF-1, and VEGF levels, and a 40- to 45-minute, 24-session, continuous 8-week AE training program significantly increased BDNF levels. No significant difference in response to any other AE intervention was found in other serum biomarkers. The findings suggest that AE can significantly increase BDNF, IGF-1, and VEGF across different AE protocols in survivors of stroke. However, more research is needed to determine the optimal exercise intensity and modalities, specifically in survivors of acute and subacute stroke, and how this may relate to functional outcomes.
Descriptor Terms: BIOCHEMISTRY, BRAIN, EXERCISE, LITERATURE REVIEWS, STROKE.

Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Limaye, Neeraj S. , Carvalho, Lilian B. , Kramer, Sharon. (2021). Effects of aerobic exercise on serum biomarkers of neuroplasticity and brain repair in stroke: A systematic review. Archives of Physical Medicine and Rehabilitation , 102(8), Pgs. 1633-1644. Retrieved 9/26/2021, from REHABDATA database.