More reasons for my coffee intake. Earlier ones here:
Well, I've been touting coffee for preventing dementia and Parkinsons for years.
How coffee protects against Parkinson’s Aug. 2014
Coffee May Lower Your Risk of Dementia Feb. 2013
And this: Coffee's Phenylindanes Fight Alzheimer's Plaque December 2018
Cognitive recovery in patients with post-stroke subjective cognitive complaints Coffee in here also.
CVD lowering risk here:
The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank
The latest here:
Coffee intake linked to longer prostate cancer-specific survival for certain men
High coffee consumption appeared associated with increased prostate cancer-specific survival among men with the CYP1A2 AA caffeine metabolism genotype, according to study results published in European Association of Urology.
Background
Coffee contains several compounds that lower inflammation, and drinking coffee may reduce the risk for prostate cancer. However, few studies have examined whether coffee intake or caffeine metabolism genes can affect the risk for cancer progression among men who have been diagnosed with prostate cancer, according to a press release from The University of Texas MD Anderson Cancer Center.
Justin R. Gregg, MD, assistant professor in the department of urology at The University of Texas MD Anderson Cancer Center, and colleagues sought to examine the association between coffee intake, caffeine metabolism genotype and survival among 5,727 men with prostate cancer (median age, 63 years) included in seven studies in the PRACTICAL Consortium database. Coffee drinkers had a median consumption of 2.5 cups per day.
Researchers used multivariable-adjusted Cox proportional hazards models across pooled patient-level data to compare the effect of coffee intake on prostate cancer-specific survival and OS.
Median follow-up was 5.1 years.
Findings
Researchers identified 906 deaths in the overall cohort — 53% prostate cancer-specific.
Results showed high coffee consumption appeared associated with numerically longer prostate cancer-specific survival (HR = 0.85; 95% CI, 0.68-1.08) and OS (HR = 0.9; 95% CI, 0.77-1.07); however, the results did not reach statistical significance.
Researchers reported an association of high coffee consumption (vs. low or intermediate intake) with longer prostate cancer-specific survival among men with localized disease (HR = 0.66; 95% CI, 0.44-0.98) and — to a nonsignificant degree — among men with advanced disease (HR = 0.92; 95% CI, 0.69-1.23). The association reached significance among men with the CYP1A2 AA fast caffeine metabolism genotype (HR = 0.67; 95% CI 0.49-0.93) but not the AC/CC genotype, although researchers detected an interaction (P = .042).
No associations occurred between coffee consumption and OS in the subgroup analyses (P > .05).
Study limitations included the nominal statistical significance and residual confounding.
Looking ahead
Investigators recommended additional research to examine coffee and caffeine intake among men after a prostate cancer diagnosis to reproduce the findings, “especially when considering the development of diet-based or other clinical interventions to augment prostate cancer treatment and lengthen patient life,” Gregg and colleagues wrote.
References :
- Coffee intake and CYP1A2 AA genotype associated with longer prostate cancer survival (press release). Available at: www.newswise.com/articles/md-anderson-research-highlights-for-september-14-2022. Published Sept. 14, 2022. Accessed Oct. 6, 2022.
- Gregg JR, et al. Eur Urol Oncol. 2022;doi: 10.1016/j.euo.2022.07.008.
No comments:
Post a Comment