For our researchers to absorb since stem cells create exosomes which are the drivers of the benefits.
Exosome Derived from Human Neural Stem Cells Improves Motor Activity and Neurogenesis in a Traumatic Brain Injury Model August 2022
The latest here:
Research trends and hotspot topics of exosomes based on citespace bibliometric analysis
Keywords
1. Introduction
Tumor-derived exosomes are involved in the process of cancer development and progression. It is closely related to the clinical treatment of cancer and is a biomarker of cancer, which can be used as a raw material for liquid biopsy of cancer. Compared with traditional methods for diagnosis, prediction, and prognosis of cancer and tumors, such as biopsy, pathological section examination, and MRI, exosomes carry miRNAs and proteins as biomarkers with the advantages of non-invasiveness and accuracy, which is what makes the research on exosomes hot. Currently, exosome research is associated with tissue regeneration and repair, neurodegenerative diseases, kidney diseases, cardiovascular diseases, immune diseases, and fibrotic disease treatment. The prevalence and small size of bioactive molecules in tumor-derived exosomes can propagate oncogenic signals and epigenetic regulation, modulate the tumor microenvironment, promote immune escape, tumor progression, and drug resistance leading to cancer progression[1].In various diseases, exosomes can respond to alterations in cell or tissue status, and their detection in biological fluids may provide multi-component diagnostic readouts. Cellular components can be efficiently exchanged through exosomes, facilitating the use of exosome therapies[2] (see Fig. 4) (Fig. 4).
A growing body of data shows that stem cell differentiation is closely related to exosomes, and many researchers have isolated and used exosomes for drug delivery through molecular biology, cell biology, and other research techniques. Exosomes, which are numerous and diverse in nature, can be used as biomarkers for the detection of diseases and can contribute to the development of diseases, including renal diseases, by inducing inflammation, vascular injury, and thrombosis, in addition to modulating immune responses[3].An in-depth study of the causes of exosome release from cells and their role in intercellular communication can make a tremendous contribution to health and disease. Because exosomes are involved in important biological and pathobiological functions, the number of exosome research literature is exploding, therefore, it is necessary to retrospectively analyze the published related papers to help researchers grasp the hot directions and uncover refinements of deficiencies by systematically analyzing the changes in exosome research, and provide some reference suggestions for the follow-up of this research field.
With the development of global information technology, informatics has become a very important research tool, and bibliometrics can provide us with new ideas in daily research. Citespace is a software based on information statistics and bibliometrics, and is a tool for research hotspot analysis, research frontier detection, research evolution path analysis, research group discovery, discipline/field/knowledge crossover and flow analysis, and analysis of tools for patent technology literature.
In this paper, we will use Citespace metrological analysis software to conduct metrological analysis of exosomal literature, visualize and map different dimensions of exosomes through different metrics, and provide a comprehensive review of the current status and trends in the field of exosomes, with a view to providing new ideas for further research and application of exosomes.
More at link.
No comments:
Post a Comment