Deans' stroke musings: Significant Association Between Systemic Immune-Inflammation Index and Stroke Risk

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, September 18, 2024

Significant Association Between Systemic Immune-Inflammation Index and Stroke Risk

You described a problem, but did nothing to identify an intervention that reduces the problem to nil. Useless.

Significant Association Between Systemic Immune-Inflammation Index and Stroke Risk

The following is a summary of “Systemic immune inflammation index and risk of stroke: a cross-sectional study of the National Health and Nutrition Examination Survey 2005–2018,” published in the September 2024 issue of Neurology by Xue et al.

Researchers conducted a retrospective study examining the association between systemic immune-inflammatory index (SII) and stroke in the National Health and Nutrition Examination Survey (NHANES) dataset from 2005 to 2018.

They included 902 patients with stroke and 27,364 patients with non-stroke based on NHANES data. Additionally, SII was used as the independent variable, and stroke was used as the dependent variable. Both univariate and multivariate logistic regression analyses were analyzed to examine the link between SII and stroke. The restricted cubic spline (RCS) method assessed the nonlinear relationship between SII and stroke.

According to weighted logistic regression, the results showed a significant link between SII and stroke (OR: 1.985, 95% CI: 1.245–3.166, P=0.004). The interaction test revealed no significant difference in the SII-stroke relationship across strata (P>0.05). A positive association between SII and stroke risk (OR >1, P<0.05) was evident in the crude, model I, and model II analyses. After adjusting for confounders, the RCS analysis indicated no nonlinear positive link between SII and stroke risk.

They concluded a significant association between SII and stroke risk, although further research was needed to confirm causality and explore the underlying mechanisms.

Source: frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1431727/full