Ischemic
stroke (IS) results in the interruption of blood flow to the brain,
which can cause significant damage. The pathophysiological mechanisms of
IS include ionic imbalances, oxidative stress, neuroinflammation, and
impairment of brain barriers. Brain barriers, such as the blood–brain
barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier (B-CSF),
protect the brain from harmful substances by regulating the
neurochemical environment. Although the BBB is widely recognized for its
crucial role in protecting the brain and its involvement in conditions
such as stroke, the B-CSF requires further study. The B-CSF plays a
fundamental role in regulating the CSF environment and maintaining the
homeostasis of the central nervous system (CNS). However, the impact of
B-CSF impairment during pathological events such as IS is not yet fully
understood. In conditions like IS and other neurological disorders, the
B-CSF can become compromised, allowing the entry of inflammatory
substances and increasing neuronal damage. Understanding and preserving
the integrity of the B-CSF are crucial for mitigating damage and
facilitating recovery after ischemic stroke, highlighting its
fundamental role in regulating the CNS during adverse neurological
conditions.
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