Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, June 3, 2011

The role of neurogenesis in stroke recovery

I'm glad this is getting more exposure, talk to your researcher on how they can set up trials of this. This is only 55 pages long, a brief afternoons read. This is quite good because it pretty much puts together a lot of the neurogenesis factors that I blogged about in isolation. Because of that I won't have to go back to college to get a degree in the brain.
http://igitur-archive.library.uu.nl/student-theses/2011-0531-200812/The%20role%20of%20neurogenesis%20in%20stroke%20recovery%20Final%20Master%20Thesis%20WAdM.pdf
This review investigates the role of neurogenesis after stroke. Neural stem cells reside in the SVZ of the adult mammal, including humans. In response to stroke, proliferation in the SVZ is upregulated, giving rise to neuroblasts that migrate to the ischemic area. Here, some of them differentiate into mature neuronal cell types and survive long-term. Signs of integration have been found, but the capacity of these newborn neurons to replace neurons lost after stroke is not well understood. The mechanisms that govern proliferation, migration, differentiation, integration and survival of newborn neural precursors and neurons are investigated. The role of the vasculature, specialized niches in the SVZ, astrocytes and angiogenesis during the poststroke neurogenic response receive attention. A range of factors that have been shown to influence the neurogenic response are reviewed. It becomes clear that the role of the neurogenic response after stroke in repairing the brain is not well understood. The positive effect on stroke recovery that is associated with neurogenesis may be the result of functional integration, trophic support, neuroprotection, angiogenesis, or a combination. Taking advantage of the neurogenic capacity of the brain in stroke therapy seems promising, but many difficulties remain to be overcome.

page 15 has this section:Neurogenesis in the adult SVZ in response to stroke
page 21 has this section:Stroke-induced migration of neuroblasts from the SVZ to the ischemic area
page 26 has this section:Angiogenesis and the role of the vasculature after stroke
page 31 has this section:Fate of newborn cells migrating to ischemic areas: differentiation, survival and integration
So after all this write to your stroke associations and ask what they are doing to test out these possibilities.
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