So it seems even after you get MCI you can ameliorate it with exercise. But of course more research is needed and never do anything like this without your doctors ok. Danger, danger Will Robinson.
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0061483
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Takao Suzuki
mail,
-
Hiroyuki Shimada,
-
Hyuma Makizako,
-
Takehiko Doi,
-
Daisuke Yoshida,
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Kengo Ito,
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Hiroshi Shimokata,
-
Yukihiko Washimi,
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Hidetoshi Endo,
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Takashi Kato
- Published: April 09, 2013
- DOI: 10.1371/journal.pone.0061483
Abstract
Background
To
examine the effect of multicomponent exercise program on memory
function in older adults with mild cognitive impairment (MCI), and
identify biomarkers associated with improvement of cognitive functions.
Methodology/Principal Findings
Subjects
were 100 older adults (mean age, 75 years) with MCI. The subjects were
classified to an amnestic MCI group (n = 50) with neuroimaging measures,
and other MCI group (n = 50) before the randomization. Subjects in each
group were randomized to either a multicomponent exercise or an
education control group using a ratio of 1:1. The exercise group
exercised for 90 min/d, 2 d/wk, 40 times for 6 months. The exercise
program was conducted under multitask conditions to stimulate attention
and memory. The control group attended two education classes. A
repeated-measures ANOVA revealed that no group × time interactions on
the cognitive tests and brain atrophy in MCI patients. A sub-analysis of
amnestic MCI patients for group × time interactions revealed that the
exercise group exhibited significantly better Mini-Mental State
Examination (
p = .04) and logical memory scores (
p = .04), and reducing whole brain cortical atrophy (
p<.05)
compared to the control group. Low total cholesterol levels before the
intervention were associated with an improvement of logical memory
scores (
p<.05), and a higher level of brain-derived neurotrophic factor was significantly related to improved ADAS-cog scores (
p<.05).
Conclusions/Significance
The
results suggested that an exercise intervention is beneficial for
improving logical memory and maintaining general cognitive function and
reducing whole brain cortical atrophy in older adults with amnestic MCI.
Low total cholesterol and higher brain-derived neurotrophic factor may
predict improvement of cognitive functions in older adults with MCI.
Further studies are required to determine the positive effects of
exercise on cognitive function in older adults with MCI.
Trial Registration
UMIN-CTR UMIN000003662
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