http://nro.sagepub.com/content/20/1/29.abstract?etoc
- 1Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
- 2Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Mexico
- 3Department of Physiology, Anatomy and Cellular Biology, Universidad Pablo de Olavide, Sevilla, Spain
- Antonio Rodríguez-Moreno, Laboratory of Cellular Neuroscience and Plasticity, Department of Physiology, Anatomy and Cellular Biology, University Pablo de Olavide, Ctra. de Utrera, Km. 1, 41013, Sevilla, Spain; Talvinder S. Sihra, Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK Email: arodmor@upo.es; t.sihra@ucl.ac.uk
Abstract
Ionotropic glutamate receptors of the N-methyl-d-aspartate
(NMDA)- and AMPA-type, as well as metabotropic glutamate receptors have
been extensively invoked in plasticity.
Until relatively recently, however, kainate-type
receptors (KARs) had been the most elusive to study because of the lack
of
appropriate pharmacological tools to specifically
address their roles. With the development of selective glutamate
receptor
antagonists, and knockout mice with specific KAR
subunits deleted, the functions of KARs in neuromodulation and synaptic
transmission,
together with their involvement in some types of
plasticity, have been extensively probed in the central nervous system.
In
this review, we summarize the findings related to
the roles of KARs in short- and long-term forms of plasticity, primarily
in the hippocampus, where KAR function and synaptic
plasticity have received avid attention.
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