Deans' stroke musings: Effect of Exercise on Neurodegeneration in Neurological Disorders

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, January 31, 2014

Effect of Exercise on Neurodegeneration in Neurological Disorders

Demand your doctor find out exactly how much exercise you should be getting. You do want to not be in the 33% of stroke survivors that get dementia.
http://link.springer.com/chapter/10.1007/978-3-319-04111-7_5

Akhlaq A. Farooqui

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Abstract

Exercise induces neuroprotection not only by increasing blood flow throughout the brain, elevating levels of neurotrophins and neurotransmitters, inducing neurogenesis in the hippocampus, and increasing neuroplasticity, but also by decreasing brain atrophy, reducing neuroinflammation, and oxidative stress. Molecular mechanisms and signal transduction pathways by which exercise exerts its beneficial effects are not fully understood. However, it is becoming increasingly evident that exercise upregulates the expression of BDNF, a growth factor, which promotes synaptic plasticity and cognition. In addition, physical activity reduces blood pressure, obesity, and type II diabetes, which are risk factors for stroke, AD, PD, and depression. In animal models of stroke, AD, PD, and depression, exercise produces beneficial effect by reducing levels of proinflammatory lipid mediators and retarding the accumulation of abnormal proteins, such as β-amyloid in animal models of AD and α-synuculin in animal models of PD.