http://www.ncbi.nlm.nih.gov/pubmed/24268028
Grimoldi N, Colleoni F, Tiberio F, Vetrano IG, Cappellar A, Costa A, Belicchi M, Razini P, Giordano R, Spagnoli D, Pluderi M, Gatti S, Morbin M, Gaini SM, Rebulla P, Bresolin N, Torrente Y.
Abstract
We
previously developed a collagen tube filled with autologous
skin?derived stem cells (SDSCs) for bridging long rat sciatic nerve
gaps. Here we present a case report describing a compassionate use of
this graft for repairing poly?injured motor and sensory nerves of upper
arms of a patient. Preclinical assessment was performed with
collagen?SDSCs implantation in rats after sectioning sciatic nerve. For
the patient, during the 3?year follow?up period, functional recovery of
injured median and ulnar nerves was assessed by pinch gauge test and
static two?point discrimination and touch test with monofilaments, along
with electrophysiological and MRI examinations. Preclinical experiments
in rats revealed rescue of sciatic nerve and no side effects of
patient?derived SDSCs transplantation (30 and 180 days of treatment). In
the patient treatment, motor and sensory functions of the median nerve
demonstrated ongoing recovery post?implantation during the follow?up
period. The results indicate that the collagen/SDSCs artificial nerve
graft could be used for surgical repair of larger defects in major
lesions of peripheral nerves, increasing patient quality of life by
saving the upper arms from amputation.
I hope and believe that someday stem cells will be useful for brain injuries and many other things. That is why I spent a small fortune to bank both of my son's stem cells from their cord blood at birth. While I hope we never need it, I feel better knowingwe saved it and are supporting the research that will hopefully find uses for it!
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