Whom is following this with human clincal trials?
http://www.utsouthwestern.edu/newsroom/news-releases/year-2014/june/stroke-bibb.html
A drug that blocks the action of the enzyme Cdk5 could substantially
reduce brain damage if administered shortly after a stroke,
UT Southwestern Medical Center research suggests.
The findings, reported in the June 11 issue of the Journal of
Neuroscience, determined in rodent models that aberrant Cdk5 activity
causes nerve cell death during stroke.
“If you inhibit Cdk5, then the vast majority of brain tissue stays alive without oxygen for up to one hour,” said Dr. James Bibb, Associate Professor of Psychiatry and Neurology and Neurotherapeutics at UT Southwestern and senior author of the study. “This result tells us that Cdk5 is a central player in nerve cell death.”
More importantly, development of a Cdk5 inhibitor as an acute neuroprotective therapy has the potential to reduce stroke injury.
“If we could block Cdk5 in patients who have just suffered a stroke,
we may be able to reduce the number of patients in our hospitals who
become disabled or die from stroke. Doing so would have a major impact
on health care,” Dr. Bibb said.
While several pharmaceutical companies worked to develop Cdk5
inhibitors years ago, these efforts were largely abandoned since
research indicated blocking Cdk5 long-term could have detrimental
effects. At the time, many scientists thought aberrant Cdk5 activity
played a major role in the development of Alzheimer’s disease and that
Cdk5 inhibition might be beneficial as a treatment.
Based on Dr. Bibb’s research and that of others, Cdk5 has both good
and bad effects. When working normally, Cdk5 adds phosphates to other
proteins that are important to healthy brain function. On the flip side,
researchers have found that aberrant Cdk5 activity contributes to nerve
cell death following brain injury and can lead to cancer.
“Cdk5 regulates communication between nerve cells and is essential
for proper brain function. Therefore, blocking Cdk5 long-term may not be
beneficial,” Dr. Bibb said. “Until now, the connection between Cdk5 and
stroke injury was unknown, as was the potential benefit of acute Cdk5
inhibition as a therapy.”
In this study, researchers administered a Cdk5 inhibitor directly
into dissected brain slices after adult rodents suffered a stroke, in
addition to measuring the post-stroke effects in Cdk5 knockout mice.
“We are not yet at a point where this new treatment can be given for
stroke. Nevertheless, this research brings us a step closer to
developing the right kinds of drugs,” Dr. Bibb said. “We first need to
know what mechanisms underlie the disease before targeted treatments can
be developed that will be effective. As no Cdk5 blocker exists that
works in a pill form, the next step will be to develop a systemic drug
that could be used to confirm the study’s results and lead to a clinical
trial at later stages.”
Currently, there is only one FDA-approved drug for acute treatment of
stroke, the clot-busting drug tPA. Other treatment options include
neurosurgical procedures to help minimize brain damage.
Additional UT Southwestern scientists from the Department of
Psychiatry who contributed to this study were lead author and former
postdoctoral researcher Dr. Douglas Meyer; postdoctoral researcher Dr.
Melissa Torres-Altoro; Instructor Dr. Florian Plattner; and former
postdoctoral researcher Dr. Janice Kansy.
The work was supported by grants from the National Institutes of
Health. Pharmaceutical company Boehringer Ingelheim provided the
Cdk5-inhibiting compound indolinone used in the study.
This work is just one of numerous cutting-edge stroke research
studies taking place at UT Southwestern, where patients have access to
the newest treatments and clinical trials due in part to the stroke
center’s recent Advanced Comprehensive Stroke Center certification. This
designation is the highest level of certification for stroke care by
The Joint Commission. UT Southwestern’s Robert D. Rogers Advanced
Comprehensive Stroke Center offers the most advanced treatment available
from a multidisciplinary team of vascular neurologists, endovascular
specialists, vascular surgeons, neuro-radiologists and
neuro-intensivists who are on call 24 hours a day to treat stroke
patients.
For information on UT Southwestern’s certification as an Advanced Comprehensive Stroke Center and our stroke patient outcomes, visit UTSW Medicine.
About UT Southwestern Medical Center
UT Southwestern, one of the premier academic medical centers in the
nation, integrates pioneering biomedical research with exceptional
clinical care and education. The institution’s faculty includes many
distinguished members, including six who have been awarded Nobel Prizes
since 1985. Numbering more than 2,700, the faculty is responsible for
groundbreaking medical advances and is committed to translating
science-driven research quickly to new clinical treatments. UT
Southwestern physicians provide medical care in 40 specialties to nearly
91,000 hospitalized patients and oversee more than 2 million outpatient
visits a year.
Use the labels in the right column to find what you want. Or you can go thru them one by one, there are only 29,112 posts. Searching is done in the search box in upper left corner. I blog on anything to do with stroke.DO NOT DO ANYTHING SUGGESTED HERE AS I AM NOT MEDICALLY TRAINED, YOUR DOCTOR IS, LISTEN TO THEM. BUT I BET THEY DON'T KNOW HOW TO GET YOU 100% RECOVERED. I DON'T EITHER, BUT HAVE PLENTY OF QUESTIONS FOR YOUR DOCTOR TO ANSWER.
Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.
What this blog is for:
My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.
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Switching from long term use in Alzheimer's to brief use after stroke could make a difference. As you have pointed out we need more than tPA.
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