If you want something like this you are going to have to scream at your doctors because they will never try something new that might save a whole slew of your neurons. And what the hell are you paying them for? To sit around and watch your neurons die in the neuronal cascade of death?
http://stroke.ahajournals.org/content/45/7/2093.abstract?etoc
- Correspondence to Kevin C. Brennan, MD, 383 Colorow Dr, Room 364, Salt Lake City, UT 84103. E-mail k.c.brennan@hsc.utah.edu.
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↵* Drs López-Valdés and Clarkson contributed equally.
Abstract
Background and Purpose—Stroke
treatment is constrained by limited treatment windows and the clinical
inefficacy of agents that showed preclinical
promise. Yet animal and clinical data suggest
considerable poststroke plasticity, which could allow treatment with
recovery-modulating
agents. Memantine is a well-tolerated
N-methyl-D-aspartate glutamate receptor antagonist in common use for Alzheimer disease.
Methods—Memantine, 30 mg/kg per day, or vehicle, was delivered chronically in drinking water beginning >2 hours after photothrombotic
stroke.
Results—Although
there was no difference in infarct size, behavior, or optical intrinsic
signal maps in the first 7 days after stroke,
mice treated chronically with memantine
showed significant improvements in motor control, measured by cylinder
test and grid-walking
performance, compared with vehicle-treated
animals. Optical intrinsic signal revealed an increased area of forepaw
sensory
maps at 28 days after stroke. There was
decreased reactive astrogliosis and increased vascular density around
the infarcted
cortex. Peri-infarct Western blots revealed
increased brain-derived neurotrophic factor and
phosphorylated-tropomyosin–related
kinase-B receptor expression.
Conclusions—Our
results suggest that memantine improves stroke outcomes in an apparently
non-neuroprotective manner involving increased
brain-derived neurotrophic factor signaling,
reduced reactive astrogliosis, and improved vascularization, associated
with
improved recovery of sensory and motor
cortical function. The clinical availability and tolerability of
memantine make it
an attractive candidate for clinical
translation.
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