http://www.sciencemag.org/content/344/6189/1250.abstract
- A. S. Wahl1,2,*,
- W. Omlor2,
- J. C. Rubio3,
- J. L. Chen2,
- H. Zheng3,
- A. Schröter4,
- M. Gullo1,2,
- O. Weinmann1,2,
- K. Kobayashi5,
- F. Helmchen2,
- B. Ommer3,
- M. E. Schwab1,2,*
+ Author Affiliations
- ↵*Corresponding author. E-mail: schwab@hifo.uzh.ch (M.E.S.); wahl@hifo.uzh.ch (A.S.W.)
The brain exhibits limited capacity for
spontaneous restoration of lost motor functions after stroke.
Rehabilitation is the
prevailing clinical approach to augment
functional recovery, but the scientific basis is poorly understood.
Here, we show
nearly full recovery of skilled forelimb
functions in rats with large strokes when a growth-promoting
immunotherapy against
a neurite growth–inhibitory protein was applied
to boost the sprouting of new fibers, before stabilizing the newly
formed
circuits by intensive training. In contrast,
early high-intensity training during the growth phase destroyed the
effect and
led to aberrant fiber patterns. Pharmacogenetic
experiments identified a subset of corticospinal fibers originating in
the
intact half of the forebrain, side-switching in
the spinal cord to newly innervate the impaired limb and restore skilled
motor
function.
From another writeup on it.
The “medication” is made up of antibodies against the so-called Nogo protein that prevents nerve growth and was discovered by Schwab and his colleagues nearly 20 years ago.
From another writeup on it.
The “medication” is made up of antibodies against the so-called Nogo protein that prevents nerve growth and was discovered by Schwab and his colleagues nearly 20 years ago.
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