Deans' stroke musings: Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 13, 2016

Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

Coffee is a wonder drug. Why isn't it constantly available for stroke survivors? It would enhance movement, you would have to get fast to the bathroom numerous times during the day, as long as you weren't catheterized. That would drive your recovery even more. 112 posts on coffee so you can keep up with your 'doctors knowledge'.
https://www.mdlinx.com/family-medicine/medical-news-article/2016/12/13/coffee-chlorogenic-acid-vascular-phenolics-flow/6965864/?

Clinical Nutrition, 12/13/2016

Mills CE, et al. – The researchers performed this work to inspect the effect of coffee intake rich in chlorogenic acid on human vascular function and whether chlorogenic acids (CGAs) are involved in potential effects. The results of this study reveal that coffee intake acutely enhances human vascular function, an effect, in part, mediated by 5–CQA and its physiological metabolites.

Methods

For the purpose of this study, two acute randomized, controlled, cross-over human intervention trials were conducted.
The effect of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilation (FMD) was evaluated in 15 healthy male subjects.
In a second intervention trial conducted with 24 healthy male subjects, the effect of pure 5-caffeoylquinic acid (5-CQA), the main CGA in coffee (5-CQA; 450 mg and 900 mg) on FMD was also examined.

Results

Researchers observed a bi-phasic FMD response after low and high polyphenol, (89 mg and 310 mg CGA) intake, with increments at 1 (1.10 ± 0.43% and 1.34 ± 0.62%, respectively) and 5 (0.79% ± 0.32 and 1.52% ± 0.40, respectively) hours post coffee consumption.
The results of this study showed that FMD responses to coffee intake was closely paralleled by the appearance of CGA metabolites in plasma, notably 3-, 4- and 5-CQA and ferulic-4'-O-sulfate at 1 h and isoferulic-4'-O-glucuronide and ferulic-4'-O-sulfate at 5 h.
The findings demonstrated that intervention with purified 5-CQA (450 mg) also led to an improvement in FMD response relative to control (0.75 ± 1.31% at 1 h post intervention, p = 0.06) and concomitant appearance of plasma metabolites.

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