Association between total-Tau and brain atrophy one year after first-ever stroke

So what the fuck is the solution? I don't care how well you describe the problem, it is totally useless without a solution. Once again more followup needed which will never occur. Maybe some of these might help which your doctor knows nothing about. How fucking incompetent is your doctor and stroke hospital? Don't do these on your own

From June, 2013;

Low Diastolic Pressure Linked to Brain Atrophy

And this from November, 2012:

Relationship between Physical Activity and Brain Atrophy Progression.

And from September, 2014: 

Lack of sleep may shrink your brain

From June, 2013:

Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment

 

Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial

Study shows that IVIG could prevent brain atrophy, delay onset of Alzheimer's disease Oct. 2015

The latest here:
Association between total-Tau and brain atrophy one year after first-ever stroke

• Hege Ihle-HansenEmail author,
• Guri Hagberg,
• Brynjar Fure,
• Bente Thommessen,
• Morten W. Fagerland,
• Anne R. Øksengård,
• Knut Engedal and
• Per Selnes

BMC NeurologyBMC series – open, inclusive and trusted201717:107

DOI: 10.1186/s12883-017-0890-6

©  The Author(s). 2017

Received: 31 January 2017

Accepted: 29 May 2017

Published: 5 June 2017

Open Peer Review reports

Abstract

Background

Although the most serious consequence of neuronal ischemia is acute neuronal death, mounting evidence suggests similarities between stroke and neurodegenerative disease. Brain atrophy visualized on structural MRI and pathological cerebrospinal fluid (CSF) concentrations of microtubule-associated protein tau (T-tau) and phosphorylated microtubule-associated protein tau indicate neurofibrillary degeneration. We aimed to explore the association between CSF T-tau and brain atrophy 1 year post-stroke.

Methods

We included 210 patients with first-ever ischemic stroke or transitory ischemic attack without pre-existing cognitive impairment. After 12 months, subjects underwent MRI, and CSF biomarkers were assessed. Using SIENAX (part of FSL), ventricular CSF volume and total brain volume were estimated and normalized for subject head size. The association between T-tau as explanatory variable and ventricular and total brain volume as outcome variables were studied using linear regression.

Results

One hundred eighty-two patients completed the follow-up. Forty-four had a lumbar puncture. Of these, 31 had their MRI with identical scan parameters. Mean age was 70.2 years (SD 11.7). Ventricular volume on MRI was significantly associated with age, but not with gender. In the multiple regression model, there was a significant association between T-tau and both ventricular (beta 0.44, 95% CI 376.3, 394.9, p = 0.021) and global brain volume (beta −0.50, 95% CI −565.9, −78.3, p = 0.011). There was no significant association between CSF T-tau 1 year post-stroke and baseline volumes.

Conclusion

T-tau measured 1 year post-stroke is associated with measures of brain atrophy. The findings indicate that acute stroke may enhance or trigger tau-linked neurodegeneration with loss of neurons.

Trial registration

Clinicaltrials.gov NCT00506818, July 23, 2007.

Inclusion from February 2007, randomization and intervention from May 2007 and trial registration in July 2007.