Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, November 10, 2017

Poor Heart Function Cuts Memory Center Blood Flow

Is this your memory problem rather than the stroke?  Or is your doctor blinded by Occams' razor?
https://www.medpagetoday.com/cardiology/dementia/69142?

Effect on par with 15 to 20 years of aging, researchers say

  • by Senior Associate Editor, MedPage Today
Reduced cardiac output was associated with accelerated brain aging in terms of blood flow to memory processing areas, an observational study showed.
Lower cardiac index on echocardiography -- adjusted for mild cognitive impairment (MCI), age, education, carriage of the Alzheimer's APOE ε4 gene, and other factors -- correlated to significantly lower left and right temporal lobe blood flow measured on MRI, Angela Jefferson, PhD, of Vanderbilt University Medical Center in Nashville, and colleagues reported online in Neurology.
In the left temporal lobe, there was 2.4 mL less flow per 100 g of tissue/minute for every one unit decrease in cardiac index. In the right temporal lobe, each unit lower cardiac index was associated with 2.5 mL less of blood per 100 g of tissue/minute. These apparent effects were equivalent to the decrease expected over 15 to 20 years of aging.
Other areas of the brain and hypercapnia-induced cerebrovascular reactivity didn't show significant associations.
The Vanderbilt Memory & Aging Project study included 314 people (average age 73) without heart failure, stroke, or dementia at baseline, although 39% had MCI.
A secondary analysis for interaction between cardiac index and cognitive diagnosis, showed the associations held only among cognitively normal participants, not those with MCI. But the findings were independent of prevalent cardiovascular disease.
"Our results suggest mechanisms that regulate blood flow may become more vulnerable as a person ages, even before cognitive impairment sets in," Jefferson said in a press release. "This important observation warrants further study. It is also possible the temporal lobes, where Alzheimer's disease first begins, may be especially vulnerable due to a less extensive network of sources of blood flow. If we can better understand how this process works, we could potentially develop prevention methods or treatments."
The researchers cautioned that with cross-sectional methodology, the results could not determine causality. Also, the largely white, well-educated and healthy population studied might limit generalizability.
"Longitudinal studies are needed to understand the temporal nature of associations reported here," Jefferson's group wrote, adding, "Further investigation into mechanisms linking cardiac index and regional cerebral blood flow is warranted to identify primary prevention targets or therapeutic interventions."
The study was supported by the National Institute on Aging, National Institute of Neurological Disorders and Stroke, Alzheimer's Association, American Heart Association, Vanderbilt Clinical Translational Science Award, and the Vanderbilt Memory & Alzheimer's Center.
Jefferson and co-authors disclosed no relevant relationships with industry.

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