Deans' stroke musings: Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, November 10, 2017

Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons

How is your doctor and therapists accomplishing your running? So you can get the benefits of neurogenesis. I don't care that this is in mice, your doctor should have enough brains to be able to extrapolate this to humans.

Running reorganizes the circuitry of one-week-old adult-born hippocampal neurons

Sah N¹, Peterson BD¹, Lubejko ST¹, Vivar C², van Praag H³.

Author information

Abstract

Adult hippocampal neurogenesis is an important form of structural and functional plasticity in the mature mammalian brain. The existing consensus is that GABA regulates the initial integration of adult-born neurons, similar to neuronal development during embryogenesis. Surprisingly, virus-based anatomical tracing revealed that very young, one-week-old, new granule cells in male C57Bl/6 mice receive input not only from GABAergic interneurons, but also from multiple glutamatergic cell types, including mature dentate granule cells, area CA1-3 pyramidal cells and mossy cells. Consistently, patch-clamp recordings from retrovirally labeled new granule cells at 7-8 days post retroviral injection (dpi) show that these cells respond to NMDA application with tonic currents, and that both electrical and optogenetic stimulation can evoke NMDA-mediated synaptic responses. Furthermore, new dentate granule cell number, morphology and excitatory synaptic inputs at 7 dpi are modified by voluntary wheel running. Overall, glutamatergic and GABAergic innervation of newly born neurons in the adult hippocampus develops concurrently, and excitatory input is reorganized by exercise.

PMID:: 28883658
PMCID:: PMC5589841
DOI:: 10.1038/s41598-017-11268-z

Free PMC Article

Gretchen Reynolds points to work by van Praag and collaborators showing that a week of activity rather than inactivity (in adult male rats) increases both the formation of new nerve cells in the hippocampus and the richness of their interactions. The new cells had more and longer dendrites, more of which led to spatial memory areas.