Inflammation can occur in the body in several forms, and a blood test known as CRP (C-reactive protein) is a common way to measure it. Acute inflammation occ
The associations of lipids and lipid ratios with stroke: A prospective cohort study
First published: 21 November 2018
Funding information: The study was supported by the National Natural Science Foundation, China (No. 81573259).
Abstract
Lipids and lipid ratios have been proven to be associated
with cardiovascular disease; however, their relationships with stroke
and stroke subtypes had not been fully understood. This study aims to
assess the associations of lipids and lipid ratios with type‐specific
stroke and compare their predictive capacities for stroke occurrence. In
this prospective cohort study, a total of 42 005 Chinese participants
aged 20 to 80 who were free of stroke at baseline were included and
selected into subgroups of stroke subtypes (ischemic, hemorrhagic, and
total). Total stroke outcome included a combination of ischemic and
hemorrhagic stroke. Over an average follow‐up of 3.6 years, 781
participants developed stroke (623 ischemic and 158 hemorrhagic). In
men, the highest TC/HDL‐C quartile was significantly associated with
increased ischemic stroke risk (multivariable‐adjusted hazard ratio
[HR], 1.52, 95% confidence interval [CI], 1.14‐2.03) and total stroke
risk (HR, 1.45, 95% CI, 1.12‐1.87), and TC/HDL‐C had the highest area
under the receiver operating characteristic curve (AUC) for predicting
ischemic (AUC, 0.868) and total stroke (AUC, 0.874). In women, the
highest TG quartile was significantly associated with increased risk of
ischemic (HR, 1.99, 95% CI, 1.11‐3.59) and total stroke (HR, 1.85, 95%
CI, 1.07‐3.20), with AUCs of 0.850 and 0.861, respectively. No lipid
variables were significantly associated with hemorrhagic stroke in both
sex. In conclusion, TC/HDL‐C ratio may better predict stroke risk in
men, whereas TG was more valuable in predicting stroke risk in women.
TC/HDL‐C and TG may help to discriminate high stroke risk individuals
and serve as potential targets for stroke prevention.
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